Cheikh Diack

TL;DR: Model-based characterization of best-corrected visual acuity time profiles of patients with neovascular age-related macular degeneration under ranibizumab or sham treatment based on 24-month observations of BCVA found that a composite score based on seven patient characteristics prior to treatment could be used to discriminate patients with predicted insufficient response to anti–vascular endothelial growth factor treatment.

TL;DR: A Markov model was developed to consider the high correlation in the data and quantitatively compared sleep disturbance in telemetered rats induced by methylphenidate and of a new chemical entity (NCE), showing that both compounds induce sleep fragmentation with methyl phenidate being fivefold more potent compared to the NCE.

TL;DR: The final model indicates that adequate drug exposure plus a favourable immune environment are associated with prolonged OS in HCC patients treated with codrituzumab.

TL;DR: The C-QT model for basmisanil can be used to derive the QT interval corrected changes in heart rate (QTc) and thus inform cardiac safety strategy in later development without the need for a separate, dedicated study.

TL;DR: The population PK model supported that dissolution- and solubility-limited absorption from the proximal and distal intestine alone explains the non-linear PK of RO5459072 in fasted state and the linear PK in fed state.