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Chelsie L Brewer
Researcher at University of Cincinnati Academic Health Center
Publications - 9
Citations - 112
Chelsie L Brewer is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Population & Dynorphin. The author has an hindex of 5, co-authored 6 publications receiving 51 citations. Previous affiliations of Chelsie L Brewer include Stanford University & University of Cincinnati.
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Journal ArticleDOI
The Development of Pain Circuits and Unique Effects of Neonatal Injury
TL;DR: The need to account for age as an independent variable in basic and clinical pain research is emphasized, and to consider the distinct qualities of the pediatric population when designing novel strategies for pain management is considered.
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Adolescent sleep shapes social novelty preference in mice
TL;DR: In this article , the authors identify a critical role of sleep and dopaminergic activity in the development of social interaction behavior in the Shank3-mutant mice, improving sleep or rectifying VTA activity during adolescence ameliorates adult social deficits.
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Neonatal Injury Evokes Persistent Deficits in Dynorphin Inhibitory Circuits within the Adult Mouse Superficial Dorsal Horn.
TL;DR: The data suggest that early-life tissue damage may persistently constrain the ability of spinal DYN interneurons to limit ascending nociceptive transmission to the adult brain.
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Postnatal maturation of spinal dynorphin circuits and their role in somatosensation
Chelsie L Brewer,Chelsie L Brewer,Lauren M Styczynski,Elizabeth K Serafin,Mark L Baccei,Mark L Baccei +5 more
TL;DR: Investigating age-dependent changes in the connectivity and function of prodynorphin (DYN)-lineage neurons in the mouse DH suggests that the spinal 'gates' controlling sensory transmission to the brain may emerge in a modality-selective manner during early life due to the postnatal tuning of inhibitory synaptic circuits within the DH.
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Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse
Elizabeth K Serafin,Alexander Chamessian,Jie Li,Xiang Zhang,Amanda McGann,Chelsie L Brewer,Temugin Berta,Mark L Baccei +7 more
TL;DR: The goal of the present study was to elucidate the gene expression profile of spinal dynorphin (pDyn)-lineage neurons throughout life and provide new insight into the potential molecular mechanisms underlying the known age-dependent changes in spinal nociceptive processing and pain sensitivity.