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Chen Feng
Researcher at Wenzhou Medical College
Publications - 8
Citations - 343
Chen Feng is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Apoptosis & Cell cycle checkpoint. The author has an hindex of 6, co-authored 6 publications receiving 218 citations.
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Journal ArticleDOI
Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells.
Renyu Lin,Ziheng Zhang,Ziheng Zhang,Lingfeng Chen,Yunfang Zhou,Peng Zou,Chen Feng,Li Wang,Guang Liang,Guang Liang +9 more
TL;DR: This study suggests that DHA specifically causes head and neck cancer cell death through contribution from both ferroptosis and apoptosis and may represent an effective strategy in head andneck cancer treatment.
Journal ArticleDOI
Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells.
Chen Feng,Yiqun Xia,Peng Zou,Miaoshan Shen,Jie Hu,Shilong Ying,Jialing Pan,Zhiguo Liu,Xuanxuan Dai,Weishan Zhuge,Guang Liang,Yeping Ruan,Yeping Ruan +12 more
TL;DR: The results show that L48H37 decreases lung cancer cell growth and colony formation and inhibits the growth of lung cancer xenografts without exhibiting toxicity, and provides evidence for a novel anti‐tumor candidate for the treatment of Lung cancer.
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Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer.
Xi Chen,Xuanxuan Dai,Peng Zou,Weiqian Chen,Vinothkumar Rajamanickam,Chen Feng,Weishan Zhuge,Chenyu Qiu,Qingqing Ye,Xiaohua Zhang,Guang Liang +10 more
TL;DR: The aim of this study was to delineate the effects of MK‐2206 on gastric cancer cells and explore the ability of combination treatments to enhance the anti‐tumour activity of MK-2206.
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Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury.
Lingfeng Chen,Lingfeng Chen,Yiyi Jin,Weitao Fu,Siyang Xiao,Chen Feng,Bo Fang,Yugui Gu,Chenglong Li,Yunjie Zhao,Zhiguo Liu,Guang Liang,Guang Liang +12 more
TL;DR: A new series of thiazolo[3,2‐a]pyrimidine derivatives based on a previously identified lead compound are designed and synthesized and evaluated their anti‐inflammatory activities, and administration of these compounds resulted in lung histopathological improvements and attenuated LPS‐induced ALI in vivo.
Journal ArticleDOI
Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3.
Vinothkumar Rajamanickam,Heping Zhu,Chen Feng,Xi Chen,Hailun Zheng,Xiaohong Xu,Qianqian Zhang,Peng Zou,Guodong He,Xuanxuan Dai,Xi Yang,Yi Wang,Zhiguo Liu,Guang Liang,Guilong Guo +14 more
TL;DR: Experimental evidence is provided that MAC CA10 effectively targets gastric cancer in preclinical models by enhancing ROS and ROS-mediated signaling and inhibited STAT3 phosphorylation and gastric xenografts tumor growth in mice.