Z
Zhiguo Liu
Researcher at Wenzhou Medical College
Publications - 99
Citations - 2017
Zhiguo Liu is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Lung injury & Curcumin. The author has an hindex of 22, co-authored 90 publications receiving 1483 citations. Previous affiliations of Zhiguo Liu include Chonnam National University.
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Anticancer molecules targeting fibroblast growth factor receptors
TL;DR: Recent advances in structure-activity relationships (SAR) of FGFR inhibitors, as well as the FGFR-targeting drug design strategies currently employed in targeting deregulated FGFRs by antibodies and small molecule inhibitors are reviewed.
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Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer
Peng Zou,Minxiao Chen,Minxiao Chen,Jiansong Ji,Weiqian Chen,Xi Chen,Shilong Ying,Junru Zhang,Ziheng Zhang,Zhiguo Liu,Shulin Yang,Guang Liang +11 more
TL;DR: This work provides a novel anticancer candidate for the treatment of gastric cancer and reveals that increased ROS generation might be an effective strategy in treating human Gastric cancer.
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Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents.
Zhiguo Liu,Longguang Tang,Peng Zou,Yali Zhang,Zhe Wang,Qilu Fang,Lili Jiang,Gaozhi Chen,Zheng Xu,Huajie Zhang,Guang Liang +10 more
TL;DR: Compound 14q is the most potent analog among them, and exhibits significant protection against LPS-induced death in septic mice, and presents a series of new analogs of curcumin as promising anti-inflammatory agents.
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Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives
Gaozhi Chen,Zhiguo Liu,Yali Zhang,Xiaoou Shan,Lili Jiang,Yunjie Zhao,Wenfei He,Zhiguo Feng,Shulin Yang,Guang Liang +9 more
TL;DR: A series of new imidazopyridines with potential therapeutic effects in acute inflammatory diseases were synthesized and screened for anti-inflammatory activities and showed excellent inhibition of the expression of inflammatory cytokines in LPS-stimulated macrophages.
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Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer
TL;DR: This Miniperspective analyses the allosteric and ATP-competitive inhibitors in terms of drug discovery, binding mechanism, and their potency and selectivity against EGFR harboring C797S mutations and provides some perspectives on new challenges and future directions in this field.