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Chen Jin

Researcher at Peking Union Medical College

Publications -  45
Citations -  948

Chen Jin is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Mesenchymal stem cell & Percutaneous coronary intervention. The author has an hindex of 15, co-authored 33 publications receiving 580 citations.

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Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19

Pei-Sen Huang, +14 more
- 01 Feb 2020 - 
TL;DR: Exosomes obtained from ATV-pretreated MSCs have significantly enhanced therapeutic efficacy for treatment of AMI possibly through promoting endothelial cell function and mediates the cardioprotective roles of MSCATV-Exo in promoting angiogenesis.
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Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance

Pei-Sen Huang, +12 more
- 10 Oct 2019 - 
TL;DR: Combinatorial delivery of exosomes and stem cells in a sequential manner effectively reduces scar size and restores heart function after AMI and may represent as an alternative promising strategy for stem cell-based heart repair and therapy.
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Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway

Xiangdong Li, +11 more
- 06 Aug 2010 - 
TL;DR: Pretreatment with a single low loading dose of TXL 1 h before ischemia reduces myocardial no-reflow and is chemia-reperfusion injury by upregulating the phosphorylation of eNOS at Ser(1179) and Ser(635), and this effect is partially mediated by the PKA pathway.
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Induction of Autophagy by Tongxinluo Through the MEK/ERK Pathway Protects Human Cardiac Microvascular Endothelial Cells From Hypoxia/Reoxygenation Injury

Hehe Cui, +8 more
- 01 Aug 2014 - 
TL;DR: Autophagy is a protective mechanism in CMECs subjected to I/R injury and TXL can promote autophagy through activation of the mitogen-activated protein kinase/ERK pathway, according to a dose-dependent manner.
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Atorvastatin treatment improves the effects of mesenchymal stem cell transplantation on acute myocardial infarction: The role of the RhoA/ROCK/ERK pathway

Qian Zhang, +8 more
- 20 Oct 2014 - 
TL;DR: ATV improves the post-infarct microenvironment via RhoA/ROCK/ERK inhibition and thus facilitates the survival and efficacy of implanted MSCs and may be not responsible for the cardiac benefits that follow MSC transplantation.