L
Li Wang
Researcher at University of North Carolina at Chapel Hill
Publications - 54
Citations - 2232
Li Wang is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Reprogramming & Medicine. The author has an hindex of 22, co-authored 46 publications receiving 1562 citations. Previous affiliations of Li Wang include Chinese Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector
Ziqing Liu,Olivia Chen,J. Blake Joseph Wall,Michael Zheng,Yang Zhou,Li Wang,Haley Ruth Vaseghi,Li Qian,Jiandong Liu +8 more
TL;DR: The effect of varying gene position and 2As on the expression of proteins encoded in bi-, tri-, or quad-cistronic constructs is characterized and results on protein expression ratios from different 2A constructs could serve to guide future utilization of 2A peptides in basic research and clinical applications.
Journal ArticleDOI
Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming
Li Wang,Ziqing Liu,Chaoying Yin,Huda Asfour,Olivia Chen,Yanzhen Li,Nenad Bursac,Jiandong Liu,Li Qian +8 more
TL;DR: The results demonstrate that stoichiometry of G, M, T protein expression influences the efficiency and quality of iCM reprogramming and will provide a valuable platform for future iCM studies.
Journal ArticleDOI
Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19
Pei-Sen Huang,Pei-Sen Huang,Li Wang,Qing Li,Xia-Qiu Tian,Jun Xu,Jun-Yan Xu,Yu-Yan Xiong,Gui-Hao Chen,Hai-Yan Qian,Chen Jin,Yuan Yu,Ke Cheng,Li Qian,Yuejin Yang +14 more
TL;DR: Exosomes obtained from ATV-pretreated MSCs have significantly enhanced therapeutic efficacy for treatment of AMI possibly through promoting endothelial cell function and mediates the cardioprotective roles of MSCATV-Exo in promoting angiogenesis.
Journal ArticleDOI
Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming
Yang Zhou,Li Wang,Haley Ruth Vaseghi,Ziqing Liu,Rui Lu,Sahar Alimohamadi,Chaoying Yin,Ji-Dong Fu,Greg G. Wang,Jiandong Liu,Li Qian +10 more
TL;DR: Reducing levels of the polycomb complex gene Bmi1 significantly enhanced induction of beating iCMs from neonatal and adult mouse fibroblasts and acts as a critical epigenetic barrier to iCM production, potentially streamlining i CM production for therapeutic purposes.
Journal ArticleDOI
Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte
Ziqing Liu,Li Wang,Joshua D. Welch,Hong Ma,Yang Zhou,Haley Ruth Vaseghi,Shuo Yu,Joseph Blake Wall,Sahar Alimohamadi,Michael Zheng,Chaoying Yin,Weining Shen,Jan F. Prins,Jiandong Liu,Li Qian +14 more
TL;DR: Single-cell transcriptomics approaches enabled us to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in iCM induction.