C
Chen Zhang
Researcher at Chengdu University of Traditional Chinese Medicine
Publications - 40
Citations - 1011
Chen Zhang is an academic researcher from Chengdu University of Traditional Chinese Medicine. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 8, co-authored 25 publications receiving 305 citations.
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Journal ArticleDOI
Metabolomics Analysis of L-Arginine Induced Gastrointestinal Motility Disorder in Rats Using UPLC-MS After Magnolol Treatment.
TL;DR: The findings suggest that magnolol has a significantly promoting effect on L-arginine induced gastrointestinal motility disorder in rats, the mechanism is to reduce the production of nitric oxide to weaken the function ofNitric oxide relaxing the gastrointestinal smooth muscle and increase the content of serotonin to promote gastrointestinal peristalsis and motility, secretion, absorption of nutrients.
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Oral colon-targeting core-shell microparticles loading curcumin for enhanced ulcerative colitis alleviating efficacy
TL;DR: In this paper, a core-shell microparticle (MP) system composed of eco-friendly materials, zein and shellac, was fabricated using a coaxial electrospray technique.
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Colonic Delivery of Celastrol-Loaded Layer-by-Layer Liposomes with Pectin/Trimethylated Chitosan Coating to Enhance Its Anti-Ulcerative Colitis Effects
Jing Xian,Xuemei Zhong,Huan Gu,Xiao Wang,Jiaxin Li,Jingjing Li,Yihan Wu,Chen Zhang,Jinming Zhang +8 more
TL;DR: In this article, a flexible oral colon-targeting delivery system, mediated by electrostatic layer-by-layer alternate deposition with pectin-trimethyl chitosan (TMC) onto liposomesloading celastrol (Cel/PT-LbL Lipo), was fabricated to enhance anti-UC efficacy.
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Exploring the Mechanism of Indigo Naturalis in the Treatment of Ulcerative Colitis Based on TLR4/MyD88/NF-κB Signaling Pathway and Gut Microbiota
TL;DR: In this paper, the anti-UC mechanism of indigo naturalis was studied by pathological section, inflammatory factor, western blot, and 16S rRNA sequencing, and the strongest anti DSS-induced UC effect was reported by indirubin and indigo.
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Strategy for osteoarthritis therapy: Improved the delivery of triptolide using liposome-loaded dissolving microneedle arrays.
Ping Zhou,Chonghao Chen,Xuan Yue,Jinming Zhang,Chi Huang,Shiyi Zhao,Anxing Wu,Xuebo Li,Yan Qu,Chen Zhang +9 more
TL;DR: Wang et al. as mentioned in this paper developed a liposome-loaded dissolving microneedle (DMN) system, which can effectively deliver poorly water-soluble triptolide (TP) and improve OA symptoms.