Cheng Guo

TL;DR: A direct and metal-free access toward fully substituted pyrazoles and its sulphenylation has been established through an iodine-mediated three-component [3 + 2] annulation of β-ketonitrile, arylhydrazines, and aryL sulfonyl hydrazides.

TL;DR: Silver-mediated C(sp3)-H functionalization and 6-endo-dig oxo-cyclization of conjugated β-alkynyl ketones have been established under oxidative conditions.

TL;DR: The electrosynthesis offers sustainable and efficient access to construct spirocyclohexadienone-containing (E)-indenes without any additional catalyst or oxidant through a sulfonyl-radical-triggered 1,6-addition and an I+-mediated ipso-cyclization cascade.

TL;DR: New I2-catalyzed multicomponent bicyclization reactions of β-ketonitriles with sulfonyl hydrazides with sulfenylating agent have been established, providing a direct and metal-free access toward unreported pyrazolo[1,5-a]pyrimidin-4-ium sulfonates.

TL;DR: The present copper-catalyzed radical-triggered fluoromethylation-spirotricyclization of enediyne- and enyne-nitrile-containing para-quinone methides was reported for the first time and used to produce a series of hitherto unreported cyclohexadienone-based pentacyclic spiroindenes with moderate to good yields and complete regioselectivity.