C
Chengxing Shen
Researcher at Shanghai Jiao Tong University
Publications - 37
Citations - 1060
Chengxing Shen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 22 publications receiving 774 citations.
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Journal ArticleDOI
Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways.
TL;DR: In vivo exosome injections in rats that underwent I/R injury significantly reduced apoptosis and the myocardial infarct size and upregulated myocardian LC3B expression as well as improved heart function.
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Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1.
TL;DR: This study provides the first evidence that miR-126 is downregulated in EPCs from diabetic patients, and impairs E PCs-mediated function via its target, Spred-1, and through Ras/ERK/VEGF and PI3K/Akt/eNOS signal pathway.
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The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT
TL;DR: It is demonstrated that MALAT1 was upregulated in patients with unstable angina and protects the endothelium from ox‐LDL‐induced endothelial dysfunction partly through competing with miR‐22‐3p for endogenous RNA.
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Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression.
TL;DR: In conclusion, metformin inhibits AGEs-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFκB pathway suppression.
Journal ArticleDOI
MicroRNA 107 partly inhibits endothelial progenitor cells differentiation via HIF-1β.
Shu Meng,Jiatian Cao,Liansheng Wang,Qing Zhou,Yi-Gang Li,Chengxing Shen,Xiao-Ping Zhang,Changqian Wang +7 more
TL;DR: It is indicated that miR-107 was up-regulated in hypoxia to prevent EPCs differentiation via its target HIF-1β.