抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Textbook of histology

Retinopathy of prematurity

principles and techniques of electron microscopy principles and techniques of electron microscopy electron microscopy and optics: general textbooks principles and techniques of electron microscopy principles and techniques of electron microscopy principles and techniques of digital holographic microscopy scanning electron microscopy cathodoluminescence of quartz introduction to transmission/scanning transmission principles and technique of fluorescence microscopy by m principles and techniques of electron microscopy: volume 1 principles of the phase contrast (electron) microscopy principles and techniques of electron microscopy lecture 1 the principles of microscopy principles in light microscopy scanning techniques in electron microscopy

Principles and Techniques of Electron Microscopy

Purpose of reviewThere is an increasing interest and availability of micro-invasive glaucoma surgery (MIGS) procedures. It is important that this increase is supported by sound, peer-reviewed evidence. This article will define MIGS, review relevant publications in the period of annual review and dis

Micro-invasive glaucoma surgery: current perspectives and future directions.

Second-generation trabecular meshwork bypass stent (istent inject) increases outflow facility in cultured human anterior segments

Prostaglandins increase trabecular meshwork outflow facility in cultured human anterior segments.

Purpose.
To examine the anatomy of Schlemm's canal (SC) and collector channels (CCs) in normal human and primary open-angle glaucoma (POAG) eyes under low and high perfusion pressure.

/pdf/anatomic-changes-in-schlemm-s-canal-and-collector-channels-1spio6l033.pdf

Anatomic changes in Schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures.

Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT).

PURPOSE To determine the effects of incorporating superparamagnetic microspheres (SPMs) into cultured human corneal endothelial cells (HCECs) and to describe preliminary experiments of HCEC transplantation, facilitated by SPMs and an external magnetic field, in a human anterior segment ex vivo model. METHODS HCECs were cultured as monolayers and incorporated with magnetite oxide SPMs (900, 300, and 100 nm) at different concentrations. Cell viability, migration toward a magnetic field, and light transmittance were measured after incorporation of the SPMs. HCEC transplantation into the eyes of human recipients was investigated by subjecting anterior segments in organ culture to an external magnetic field. Light and electron microscopy were used to assess HCEC attachment to corneal stroma. RESULTS SPMs were incorporated into the cytoplasm of HCECs after overnight incubation. None of the SPMs affected the short-term viability of cultured HCECs (P > 0.14, n = 6) or their light transmittance (P > 0.06, n = 5), although there was a trend toward decreased transmittance with the higher concentration of 900-nm SPMs. Cell migration toward a magnetic field was higher for HCECs with incorporated SPMs than for HCECs without SPMs (P < or = 0.01, n = 6), with dose-response relationships evident for the 300- and 100-nm SPMs. SPMs facilitated the attachment of HCECs to the corneal stroma in the human anterior segment model with minimal change in intracameral (intraocular) pressure. CONCLUSIONS SPMs facilitate migration of HCECs toward a magnetic source and attachment of cells to the corneal stroma without affecting cell viability or light transmittance. The human anterior segment model can be used to study HCEC transplantation.

Cheryl R. Hann

Papers

Second-generation trabecular meshwork bypass stent (istent inject) increases outflow facility in cultured human anterior segments

Prostaglandins increase trabecular meshwork outflow facility in cultured human anterior segments.

Anatomic changes in Schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures.

Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT).

Human corneal endothelial cell transplantation in a human ex vivo model.