Purpose Traditional treatment for superior sulcus non–small-cell lung cancers (SS NSCLC), radiation plus surgery, yields a 50% rate of complete resection and a 30% 5-year survival. On the basis of improved outcomes in other subsets of stage III NSCLC, this trial tested the feasibility of induction chemoradiotherapy for SS NSCLC. Patients and Methods Patients with T3-4, N0-1 SS NSCLC received two cycles of cisplatin and etoposide concurrently with radiation (45 Gy). Patients with stable or responding disease underwent thoracotomy. All patients received two more cycles of chemotherapy. Survival was calculated by the Kaplan-Meier method and prognostic factors were assessed by Cox regression analysis. Results From April 1995 to November 1999, 110 eligible patients (76 men, 34 women) were entered onto the study (78 T3, 32 T4 tumors). Induction therapy was completed by 104 (95%) patients. Of 95 patients eligible for surgery, 88 (80%) underwent thoracotomy, two (1.8%) died postoperatively, and 83 (76%) had compl...

https://ascopubs.org/doi/pdf/10.1200/jco.2006.08.2826

Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: Long-term results of Southwest Oncology Group trial 9416 (Intergroup trial 0160)

Anterior transcervical-thoracic approach for radical resection of lung tumors invading the thoracic inlet.

Induction chemoradiation and surgical resection for non-small cell lung carcinomas of the superior sulcus: Initial results of Southwest Oncology Group trial 9416 (Intergroup trial 0160)

Influence of surgical resection and brachytherapy in the management of superior sulcus tumor.

Pancoast's syndrome is a constellation of characteristic symptoms and signs that includes shoulder and arm pain along the distribution of the eighth cervical nerve trunk and first and second thoracic nerve trunks, Horner's syndrome, and weakness and atrophy of the muscles of the hand, most commonly caused by local extension of an apical lung tumor at the superior thoracic inlet.1–3 These tumors are called superior pulmonary sulcus tumors or Pancoast's tumors. Nearly 90 years after the first documented case,4 Pancoast described the clinical and radiologic findings of thoracic-inlet tumors. Pancoast mistakenly believed that these tumors emanated from epithelial rests . . .

Chi Kim Ho

Papers

Pancoast's Tumor: Irradiation or Surgery?