C
Chiara De Nuccio
Researcher at Istituto Superiore di Sanità
Publications - 30
Citations - 849
Chiara De Nuccio is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Neuroprotection. The author has an hindex of 15, co-authored 27 publications receiving 666 citations.
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Journal ArticleDOI
Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals.
Roberta De Simone,Federica Vissicchio,Cecilia Mingarelli,Chiara De Nuccio,Sergio Visentin,Maria Antonietta Ajmone-Cat,Luisa Minghetti +6 more
TL;DR: The effects of BCAAs on microglia, the main immune cells of the brain, are evaluated and it is suggested that an intermediate M1/M2 phenotype might result in a less efficient microglial response, which would promote the establishment of a low grade chronic inflammation and increase the likelihood of neurodegeneration.
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TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression
Roberta De Simone,Cristina Elena Niturad,Chiara De Nuccio,Maria Antonietta Ajmone-Cat,Sergio Visentin,Luisa Minghetti +5 more
TL;DR: In this paper, the effects of interferon-gamma, lipopolysaccharide (LPS) or transforming growth factor-β (TGF-β) addition to mixed glial cell cultures, on microglial migration in response to ADP, P2Y12 and p2Y1 mRNA expression as well as on the expression of an array of genes associated with the process of micro-glial activation were investigated.
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Triazine compounds as antagonists at Bv8-prokineticin receptors.
Gianfranco Balboni,Ilaria Lazzari,Claudio Trapella,Lucia Negri,Roberta Lattanzi,Elisa Giannini,Annalisa Nicotra,Pietro Melchiorri,Sergio Visentin,Chiara De Nuccio,Severo Salvadori +10 more
TL;DR: A new synthesis of some 1,3,5-triazin-4,6-diones as potential non peptidic prokineticin receptor antagonists are approached, containing the following substitutions: N(1), N(5), and C(2) can link an amino-ethyl-guanidine or an ethylendiamine or a 4-ethylbenzyl.
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Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations
Angela Lanciotti,Maria Stefania Brignone,Paola Molinari,Sergio Visentin,Chiara De Nuccio,Gianfranco Macchia,Chiara Aiello,Enrico Bertini,Francesca Aloisi,Tamara C. Petrucci,Elena Ambrosini +10 more
TL;DR: It is demonstrated, for the first time, that MLC1 plays a role in astrocyte osmo-homeostasis and that defects in intracellular calcium dynamics may contribute to MLC pathogenesis.
Journal ArticleDOI
Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit.
Andrea Matteucci,Roberta Cammarota,Silvia Paradisi,Monica Varano,Maria Balduzzi,Lanfranco Leo,Gian Carlo Bellenchi,Chiara De Nuccio,Giovanna Carnovale-Scalzo,G Scorcia,Claudio Frank,Cinzia Mallozzi,Annamaria M Di Stasi,Sergio Visentin,Fiorella Malchiodi-Albedi +14 more
TL;DR: The results of this study confirm the neuroprotective activity of curcumin against NMDA toxicity, possibly related to an increased level of NR2A, and encourage further studies for a possible therapeutic use ofCurcumin based on neuromodulation of NMDArs.