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Chie Negishi

Researcher at National Cancer Research Institute

Publications -  15
Citations -  486

Chie Negishi is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Metabolite & Glycine. The author has an hindex of 10, co-authored 15 publications receiving 479 citations.

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Journal ArticleDOI

Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose

Margaretha Jägerstad, +7 more
- 01 May 1984 - 
TL;DR: In this article, a mixture of creatinine, glucose and glycine was heated in diethylene glycol containing 14% water for 2 h at 128°C, and the mutagens formed were purified by XAD-2 column chromatography, acid-base partition, Sephadex LH-20 column and HPLC.
Journal ArticleDOI

Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes

Hiroko Ohgaki, +5 more
- 01 May 1984 - 
TL;DR: In rats treated with 1,8-DNP, sarcomas were induced at the sites of injection in all 10 animals tested between the 113th and 127th experimental days and some tumors induced by these chemicals were transplantable into the same strain of rats.
Journal ArticleDOI

Formation of 2-amino-3,7,8-trimethylimidazo[4,5-ƒ]quinoxaline, a new mutagen, by heating a mixture of creatinine, glucose and glycine

Chie Negishi, +7 more
- 01 Jun 1984 - 
TL;DR: 7,8-DiMeIQx is a newly identified compound which, at a dose of 1 microgram, induced 163 000 and 9900 revertants of Salmonella typhimurium TA98 and TA100, respectively, with S9 mix.
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Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.

Hiroko Ohgaki, +5 more
- 01 Jan 1985 - 
TL;DR: Three mutagenic components of diesel exhaust and air pollutants were injected subcutaneously into the back of F344 rats and 1-NP, 1,6-dinitropyrene and 1,8-DNP were demonstrated to induce sarcomas at the injection site in all 10 rats.
Journal ArticleDOI

Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials.

Mitsuhiro Tsuda, +6 more
- 01 Dec 1985 - 
TL;DR: Differential inactivation of mutagenic heterocyclic amines by nitrite and hypochlorite was used in determination of the contributions of IQ-type and non-IQ-type mutagens to the total mutagenICities of various pyrolyzed materials.