C
Chiemi Sakai
Researcher at Hiroshima University
Publications - 17
Citations - 226
Chiemi Sakai is an academic researcher from Hiroshima University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications receiving 130 citations.
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Journal ArticleDOI
Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells
Chiemi Sakai,Mari Ishida,Hideo Ohba,Hiromitsu Yamashita,Hitomi Uchida,Masao Yoshizumi,Takafumi Ishida +6 more
TL;DR: The results suggested that EPA and DHA attenuate oxidative stress-induced DNA damage in vascular endothelial cells through upregulation of NRF2-mediated antioxidant response, and omega-3 fatty acids likely help prevent cardiovascular disease, at least in part, by their genome protective properties.
Journal ArticleDOI
Biological Effects of Low-Dose Chest CT on Chromosomal DNA.
Hiroaki Sakane,Mari Ishida,Lin Shi,Wataru Fukumoto,Chiemi Sakai,Yoshihiro Miyata,Takafumi Ishida,Tomoyuki Akita,Morihito Okada,Kazuo Awai,Satoshi Tashiro +10 more
TL;DR: No effect of low-dose CT on human DNA was detected and, in the same setting, DNA double-strand breaks and chromosome aberrations increased after standard- dose CT.
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Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells
Mari Ishida,Takafumi Ishida,Satoshi Tashiro,Hitomi Uchida,Chiemi Sakai,Naoya Hironobe,Katsuya Miura,Yu Hashimoto,Koji Arihiro,Kazuaki Chayama,Yasuki Kihara,Masao Yoshizumi +11 more
TL;DR: Investigating whether smoking induces DSBs in human MNCs in vivo through examination of peripheral mononuclear cells (MNCs) found that smoking cessation for 1 month resulted in a decrease in D SBs to a level comparable to that seen in non-smokers, reinforcing the notion that the cigarette smoking inducesDSBs.
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DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters.
Wataru Fukumoto,Mari Ishida,Chiemi Sakai,Satoshi Tashiro,Takafumi Ishida,Yukiko Nakano,Fuminari Tatsugami,Kazuo Awai +7 more
TL;DR: In this paper, the authors investigated whether physical exposure parameters such as the dose index (CTDI), dose length product (DLP), and size-specific dose estimate (SSDE) are predictive of DNA damage.
Journal ArticleDOI
Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation
Batmunkh Bumdelger,Mikage Otani,Kohei Karasaki,Chiemi Sakai,Mari Ishida,Hiroki Kokubo,Masao Yoshizumi +6 more
TL;DR: The results suggest that fibrotic remodeling of the aorta induced by myofibroblast accumulation might be an important pathological event which tends to limit AngII-induced aortic dilatation in ApoE -/-Opg-/- mice.