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Chien-Ping Ko
Researcher at University of Southern California
Publications - 65
Citations - 3776
Chien-Ping Ko is an academic researcher from University of Southern California. The author has contributed to research in topics: Neuromuscular junction & Spinal muscular atrophy. The author has an hindex of 34, co-authored 64 publications receiving 3277 citations. Previous affiliations of Chien-Ping Ko include Hong Kong University of Science and Technology.
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Journal ArticleDOI
SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Nikolai Naryshkin,Marla Weetall,Amal Dakka,Jana Narasimhan,Xin Zhao,Zhihua Feng,Karen K. Y. Ling,Gary Mitchell Karp,Hongyan Qi,Woll Matthew G,Guangming Chen,Nanjing Zhang,Vijayalakshmi Gabbeta,Priya Vazirani,Anuradha Bhattacharyya,Bansri Furia,Nicole Risher,Josephine Sheedy,Ronald Kong,Jiyuan Ma,Anthony Turpoff,Chang-Sun Lee,Xiaoyan Zhang,Young-Choon Moon,Panayiota Trifillis,Ellen Welch,Joseph M. Colacino,John Babiak,Neil Gregory Almstead,Stuart W. Peltz,Loren A. Eng,Karen S. Chen,Jesse L. Mull,Maureen S. Lynes,Lee L. Rubin,Paulo Fontoura,Luca Santarelli,Daniel Haehnke,Kathleen D. McCarthy,Roland Schmucki,Martin Ebeling,Manaswini Sivaramakrishnan,Chien-Ping Ko,Sergey Paushkin,Hasane Ratni,Irene Gerlach,Anirvan Ghosh,Friedrich Metzger +47 more
TL;DR: Small molecules that alter splicing of a specific messenger RNA have beneficial effects in a model of a motor neuron disease and selective SMN2 splicing modifiers may have therapeutic potential for patients with SMA.
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Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
Hasane Ratni,Martin Ebeling,John D. Baird,Stefanie Bendels,Johan Bylund,Karen S. Chen,Nora Denk,Zhihua Feng,Luke Green,Melanie Guérard,Philippe Jablonski,Bjoern Jacobsen,Omar Khwaja,Heidemarie Kletzl,Chien-Ping Ko,Stefan Kustermann,Anne Marquet,Friedrich Metzger,Barbara Mueller,Nikolai Naryshkin,Sergey Paushkin,Emmanuel Pinard,Agnès Poirier,Michael Reutlinger,Marla Weetall,Andreas Zeller,Xin Zhao,Lutz Mueller +27 more
TL;DR: The discovery of 1 (risdiplam, RG7916, RO7034067) that focused on thorough pharmacology, DMPK and safety characterization and optimization is described, which is a promising medicine for the treatment of patients in all ages and stages with SMA.
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Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy
TL;DR: The results present a novel concept that synaptic defects occur at multiple levels of the spinal and neuromuscular circuitry in SMNΔ7 mice, and that proprioceptive spinal synapses could be a potential target for SMA therapy.
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Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy
TL;DR: It is suggested that neuromuscular denervation in vulnerable muscles is a widespread pathology in SMA, and can serve as a preparation for elucidating the biological basis of synapse loss, and for evaluating therapeutic efficacy.
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Mechanisms and Roles of Axon-Schwann Cell Interactions
TL;DR: Axons and glial cells are not only in intimate physical contact but also in constant and dynamic communication, each one influencing and regulating the development, function, and maintenance of the other.