A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been checked on a large scale and the possible reaction mechanism has also been proposed.

/pdf/amberlite-15-promoted-an-unprecedented-aza-michael-1l51pkq77r.pdf

Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds

A novel approach for the spiro-isoindolinone dihydroquinazolinones has been demonstrated from 2-aminobenzamide and 2-cyanomethyl benzoate in the presence of KHMDS as a base to get moderate yields. The reaction has been screened in various bases followed by solvents and a gram scale reaction has also been executed under the given conditions. Based on the controlled experiments a plausible reaction mechanism has been proposed. Further the substrate scope of this reaction has also been studied.

/pdf/base-mediated-spirocyclization-of-quinazoline-one-step-vjbmymyemb.pdf

Base mediated spirocyclization of quinazoline: one-step synthesis of spiro-isoindolinone dihydroquinazolinones

Immobilization of Palladium on Modified Nanoparticles and Its Catalytic Properties on Mizoroki‐Heck Reaction

A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones

The Amberlite 15 catalyzed synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones was reported. The reaction conditions were optimized by screening in different solvents and catalysts. The substrate scope of the reaction was also studied, and a plausible mechanism for the reaction was proposed.

Simple and Efficient Amberlite 15-catalyzed Synthesis of Dihydroquinazolinones

De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds

Facile Utilisation of Aldehyde Bisulfite Adducts: Synthesis of (E)-1,2- Diphenylethenes

The present invention provides an improved process of manufacturing 1-Bromo-3,5-dimethyladamantane compound of formula-IV starting from 1,3-dimethyladamantane that avoids use of liquid bromine and minimizes the use of hazardous chemicals. The present invention also provides use of 1-Bromo-3,5-dimethyladamantane prepared by the process of present invention in the process of producing Memantine hydrochloride and pharmaceutical compositions thereof.

Chikkanti Jaganmohan

Papers

De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds

A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones

Facile Utilisation of Aldehyde Bisulfite Adducts: Synthesis of (E)-1,2- Diphenylethenes

Process for preparation of memantine