C
Chris Bevan
Researcher at GlaxoSmithKline
Publications - 12
Citations - 1502
Chris Bevan is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Solvation & Partition coefficient. The author has an hindex of 12, co-authored 12 publications receiving 1404 citations. Previous affiliations of Chris Bevan include University College London & The Hertz Corporation.
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Journal ArticleDOI
Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC: A High-Throughput Alternative to log P/log D.
TL;DR: A new chromatographic hydrophobicity index (CHI) is described which can be used as part of a protocol for high-throughput (50-100 compounds/day) physicochemical property profiling for rational drug design and shows good correlation to the calculated octanol/water partition coefficient values.
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Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity
TL;DR: Several compounds showed stronger HSA binding than can be expected from their lipophilicity alone, and comparison between predicted and experimental binding affinity allows the identification of compounds that have good complementarities with any of the known binding sites.
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Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures.
TL;DR: The fast-gradient method has been validated against the isocratic log k(IAM) values using the linear free energy relationship solvation equations based on the data from 48 compounds and it was found that the relative constants of the solvation equation were very similar for the CHI(I AM) and for the log k (IAM).
Journal ArticleDOI
Rapid Method for the Estimation of Octanol / Water Partition Coefficient (Log Poct) from Gradient RP-HPLC Retention and a Hydrogen Bond Acidity Term (Sigma alpha2H)
TL;DR: A rapid method for the measurement of octanol/water partition coefficients (log P(oct) via fast gradient reversed phase retention and the calculation of the hydrogen bond acidity of the compounds is proposed.
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Rapid Gradient RP-HPLC Method for Lipophilicity Determination: A Solvation Equation Based Comparison with Isocratic Methods
TL;DR: The chromatographic hydrophobicity index (CHI) obtained from high-throughput gradient elution reversed phase HPLC with ODS column and acetonitrile mobile phase has been shown to be well correlated with log k values obtained by isocratic elution in the same system; between CHI and log k50, the correlation coefficient was 0.99 for a very diverse set of 55 compounds as mentioned in this paper.