Showing papers in "Journal of Pharmaceutical Sciences in 2000"

TL;DR: The present mini-review will remind us of the success achieved with these first-generation polymers and focus on proposals for the next-generationpolymers and attendant benefits likely to occur with these improved polymeric systems.

TL;DR: Folate-linked nanoparticles represent a potential new drug carrier for tumor cell-selective targeting in PEG-coated biodegradable nanoparticles coupled to folic acid to target the folate-binding protein.

TL;DR: This review addresses the field of improving oral bioavailability through the use of excipients that increase intestinal membrane permeability using categories of permeation enhancers, which seem to have potential to improve oral bioavailabilities of poorly absorbed compounds without causing significant intestinal damage.

TL;DR: The development and validate two mechanistic equations for predicting a priori the rabbit, rat and mouse P(t:p) of non-adipose and non-excretory tissues for 65 structurally unrelated drugs were developed and regression analyses between muscle and those of the other tissues were examined, suggesting that P (t):p of muscle is a good predictor for the P( t: p) of other tissues.

TL;DR: This mini-review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid-based dose forms.

TL;DR: Co-cultures of HT29-MTX and Caco-2 cells offer the opportunity of modifying the permeability barrier of the cell monolayers both with respect to paracellular resistance and secretory transport via P-gp.

TL;DR: To identify the transporters functional at the BBB and to examine the possible involvement of them in drug transports by molecular and physiological approaches will provide a rational basis for controlling drug distribution to the brain.

TL;DR: From these data, it can be concluded that mod.

TL;DR: The emerging role of development scientists during small-molecule lead selection and optimization has implications for graduate curricula in the pharmaceutical sciences.

TL;DR: The results demonstrate that the increased bioavailability of valganciclovir is related to its recognition as a substrate by the intestinal peptide transporter PEPT1, which is also recognized by the renal peptides transporter P EPT2 with high affinity.

TL;DR: Hf bioavailability assessed in nonlymph-cannulated animals was lower than the extent of total availability measured in lymph-cANNulated animals, suggesting either presystemic drug clearance within the lymphatics or an altered systemic clearance pattern for lymphatically transported drug.

TL;DR: This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration and highlights the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics.

TL;DR: The effects of poly(vinylpyrrolidone) (PVP) molecular weight, composition, and content on the crystallization of a model drug, MK-0591 (Form I), were investigated and changes in the carbonyl-stretching band of PVP in the solid dispersions were observed.

TL;DR: A review of recent developments in immobilized enzyme use in medicine and a brief overview of the evolution of the biosensor and bioreactor technology are presented.

TL;DR: This model may be useful in predicting the dissolution of an ionizable water insoluble drug as a function of pH and surfactant and for establishing in vitro-in vivo correlations, IVIVC, for maintaining bioequivalence of drug products.

TL;DR: The objective of this mini-review is to summarize the findings concerning the properties and the pharmaceutical applications of multicomponent complexes made of a sparingly water-soluble amino-type drug, a cyclodextrin, and a hydroxy carboxylic acid.

TL;DR: It is shown that the efficacy of low-frequency ultrasound in enhancing transdermal transport can be further increased by its combination with sodium lauryl sulfate (SLS), a well-known surfactant.

TL;DR: The hypothesis that optimizing both protein structure and T(g) by freeze-drying actin with mixtures of disaccharide and polymeric carbohydrates can optimize protein storage stability is tested.

TL;DR: PH-responsive polymeric micelles loaded with AlClPc were found to exhibit higher cytotoxicity against EMT-6 mouse mammary cells in vitro than control Cremophor EL formulation, showing the potential of poly(NIPA-co-MAA- co-ODA) for in vivo administration of water-insoluble, photosensitizing anticancer drugs.

TL;DR: The fast-gradient method has been validated against the isocratic log k(IAM) values using the linear free energy relationship solvation equations based on the data from 48 compounds and it was found that the relative constants of the solvation equation were very similar for the CHI(I AM) and for the log k (IAM).

TL;DR: It has been show that, under the authors' experimental conditions, an excess of lecithin is an essential prerequisite for a stable preparation of PLA NC.

TL;DR: PEG-lipid incorporation causes a concentration dependent reduction in LDP-mediated transfection of B16/BL6 melanoma cells, a result that can be partially attributed to a reduction in particle binding to cells.

TL;DR: Results in combination with the nontoxic character of TMC suggest that this polymer is a promising excipient in the development of solid dosage forms for the peroral delivery and intestinal absorption of octreotide.

TL;DR: An appreciation of the distribution of relaxation times and the resulting effects upon the KWW constants should be considered to be essential when working with amorphous pharmaceutical materials, especially when attempting to use relaxation time constants for predicting their physical or chemical stability.

TL;DR: Lyophilization of LPD, a novel cationic lipid-based gene delivery system, was studied and both particle size and transfection efficiency could be preserved in the presence of sufficient amount of appropriate lyoprotectant.

TL;DR: The mechanical properties were strongly affected by the type of polymer and plasticizer, resulting in major differences in the mechanical properties (flexibility) when compared with films plasticized with the more permanent, water-insoluble ATBC.

TL;DR: The faster crystallization of nifedipine than that of phenobarbital or flopropione observed at temperatures below its T(g) may be partly ascribed to its higher molecular mobility at these temperatures.

TL;DR: The results indicate that free radical oxidation may be a major degradative process for plasmid DNA in pharmaceutical formulations unless specific measures are taken to control it by the addition of free radical scavengers, specific metal ion chelators, or both.

TL;DR: It appears that agglomeration and sintering of particles caused by softening of the solid, particularly above T(g), and a resulting reduction of the particle surface/volume ratio play a major role in affecting the reaction rate by decreasing the rate of removal of the gaseous HCl product.

TL;DR: Fourier transform-Raman spectroscopy can be used to investigate the solid-state form of a drug present in the dosage form and even to determine if a mixture of forms are present.