C
Chris Oerlemans
Researcher at Utrecht University
Publications - 11
Citations - 1046
Chris Oerlemans is an academic researcher from Utrecht University. The author has contributed to research in topics: Liposome & Drug delivery. The author has an hindex of 9, co-authored 11 publications receiving 918 citations.
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Journal ArticleDOI
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
TL;DR: The combination of chelation or incorporation of imaging moieties and pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release will further improve specificity and efficacy of micelle-based drug delivery.
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Evidence for a new mechanism behind HIFU-triggered release from liposomes
TL;DR: It is concluded that neither temperature elevation nor inertial cavitation is essential for the release of both hydrophilic and lipophilic compounds from liposomes, which suggests that cavitation can be excluded as the main mechanism responsible for the triggered release.
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Triggered release of doxorubicin from temperature-sensitive poly(N-(2-hydroxypropyl)-methacrylamide mono/dilactate) grafted liposomes
Merel van Elk,Roel Deckers,Chris Oerlemans,Yang Shi,Gerrit Storm,Tina Vermonden,Wim E. Hennink +6 more
TL;DR: Temperature-sensitive liposomes with tunable release characteristics that release their content at an elevated temperature generated by high intensity focused ultrasound (HIFU) exposure can be tuned to the characteristics and the grafting density of chol-pHPMAlac, making these liposome attractive for local drug delivery using hyperthermia.
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Alginate-lanthanide microspheres for MRI-guided embolotherapy.
Chris Oerlemans,Peter R. Seevinck,Gerrit H. van de Maat,Hassan Boulkhrif,Chris J.G. Bakker,Wim E. Hennink,J. Frank W. Nijsen +6 more
TL;DR: The different alginate-lanthanide microsphere formulations developed in this study show great potential for utilization as image-guided embolotherapy agents.
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Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization
Merel van Elk,Cyril Lorenzato,Burcin Ozbakir,Chris Oerlemans,Gert Storm,F. Nijsen,Roel Deckers,Tina Vermonden,Wim E. Hennink +8 more
TL;DR: Alginate TSL-Ho-microgels are promising systems for real-time, MR-guided embolization and triggered release of drugs in vivo and can be visualized by magnetic resonance imaging after their administration.