C
Christian Hugo
Researcher at Dresden University of Technology
Publications - 160
Citations - 7135
Christian Hugo is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 37, co-authored 132 publications receiving 5742 citations. Previous affiliations of Christian Hugo include University of Erlangen-Nuremberg.
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Journal ArticleDOI
Reduced exposure to calcineurin inhibitors in renal transplantation.
Henrik Ekberg,Helio Tedesco-Silva,Alper Demirbas,Stefan Vitko,Björn Nashan,A. Gurkan,Raimund Margreiter,Christian Hugo,Josep M. Grinyó,Ulrich Frei,Yves Vanrenterghem,Pierre Daloze,Philip F. Halloran +12 more
TL;DR: In this paper, the authors evaluated the efficacy and relative toxic effects of four immunosuppressive regimens: cyclosporine, mycophenolate mofetil, and corticosteroids.
Journal ArticleDOI
Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4
Ramanjaneyulu Allam,Christina Rebecca Scherbaum,Murthy N. Darisipudi,Shrikant R. Mulay,Holger Hägele,Julia Lichtnekert,Jan H. Hagemann,Khader Valli Rupanagudi,Mi Ryu,Claudia Schwarzenberger,Bernd Hohenstein,Christian Hugo,Bernd Uhl,Christoph A. Reichel,Fritz Krombach,Marc Monestier,Helen Liapis,Kristin Moreth,Liliana Schaefer,Hans-Joachim Anders +19 more
TL;DR: The release of histones from dying cells aggravates AKI via both its direct toxicity to renal cells and its proinflammatory effects, which support the concept that renal damage triggers an innate immune response, which contributes to the pathogenesis of AKI.
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Calcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation
Henrik Ekberg,Corrado Bernasconi,Helio Tedesco-Silva,Stefan Vitko,Christian Hugo,Alper Demirbas,R Reyes Acevedo,Josep M. Grinyó,Ulrich Frei,Yves Vanrenterghem,Pierre Daloze,Philip F. Halloran +11 more
TL;DR: In the Symphony study, the largest ever prospective study in de novo kidney transplantation, over 3 years, daclizumab induction, MMF, steroids and low‐dose tacrolimus proved highly efficacious, without the negative effects on renal function commonly reported for standard CNI regimens
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Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and Thrombospondin-1 in renal disease
Duk Hee Kang,Sharon Anderson,Yoon Goo Kim,Marilda Mazzalli,Shin-ichi Suga,J. Ashley Jefferson,Katherine L. Gordon,Terry T. Oyama,Jeremy Hughes,Christian Hugo,Dontsho Kerjaschki,George F. Schreiner,Richard J. Johnson +12 more
TL;DR: In conclusion, glomerular and peritubular capillary loss in the aging kidney correlate with alterations in VEGF and TSP-1 expression and also with the development of glomerulosclerosis and tubulointerstitial fibrosis.
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Effects of Donor Pretreatment With Dopamine on Graft Function After Kidney Transplantation A Randomized Controlled Trial
Peter Schnuelle,Uwe Gottmann,Simone Hoeger,Detlef Boesebeck,Werner Lauchart,Christel Weiss,Michael Fischereder,Karl-Walter Jauch,Uwe Heemann,Martin Zeier,Christian Hugo,Przemyslaw Pisarski,Bernhard K. Krämer,Kai Lopau,Axel Rahmel,Urs Benck,Rainer Birck,Benito A. Yard +17 more
TL;DR: Donor pretreatment with low-dose dopamine reduces the need for dialysis after kidney transplantation and can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation.