C
Christian I. Schwer
Researcher at University Medical Center Freiburg
Publications - 26
Citations - 862
Christian I. Schwer is an academic researcher from University Medical Center Freiburg. The author has contributed to research in topics: Heme oxygenase & Kinase. The author has an hindex of 15, co-authored 24 publications receiving 779 citations.
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Journal ArticleDOI
Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial.
Alexander Zarbock,Christoph Schmidt,Hugo Van Aken,Carola Wempe,Sven Martens,Peter K. Zahn,Britta Wolf,Ulrich Goebel,Christian I. Schwer,Peter Rosenberger,Helene A. Haeberle,Dennis Görlich,John A. Kellum,Melanie Meersch +13 more
TL;DR: Among high-risk patients undergoing cardiac surgery, remote ischemic preconditioning significantly reduced the rate of acute kidney injury and use of renal replacement therapy and the need for renal replacement Therapy.
Journal Article
Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury.
TL;DR: H2S preconditioning mediates antiapoptotic effects in retinal I/R injury, thus exhibiting neuroprotection and could represent a novel and promising therapeutic agent to counteract neuronal injuries in the eye.
Journal ArticleDOI
Carbon Monoxide Inhalation Reduces Pulmonary Inflammatory Response during Cardiopulmonary Bypass in Pigs
Ulrich Goebel,Matthias Siepe,Anne Mecklenburg,Phillip Stein,Martin Roesslein,Christian I. Schwer,Rene Schmidt,Torsten Doenst,Klaus Geiger,Heike L. Pahl,Christian Schlensak,Torsten Loop +11 more
TL;DR: It is demonstrated that inhaled carbon monoxide significantly reduces CPB-induced inflammation via suppression of tumor necrosis factor-and-agr;, and interleukin-1-1&bgr; expression and elevation of interLEukin 10.
Journal ArticleDOI
Carbon Monoxide Releasing Molecule-2 Inhibits Pancreatic Stellate Cell Proliferation by Activating p38 Mitogen-Activated Protein Kinase/Heme Oxygenase-1 Signaling
Christian I. Schwer,Manuel Mutschler,Patrick Stoll,Ulrich Goebel,Matjaz Humar,Alexander Hoetzel,Rene Schmidt +6 more
TL;DR: It is found that CORM-2 inhibited PSC proliferation at nontoxic concentrations by arresting cells at the G0/G1 phase of the cell cycle by activation of the p38/HO-1 pathway.
Journal ArticleDOI
Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway
Christian I. Schwer,Aida M. Guerrero,Matjaz Humar,Martin Roesslein,Ulrich Goebel,Patrick Stoll,Klaus Geiger,Benedikt H. J. Pannen,Alexander Hoetzel,Rene Schmidt +9 more
TL;DR: Evidence is provided that HO-1 induction contributes to the inhibitory effect of curcumin on PSC proliferation and thus may provide a novel strategy in the prevention of pancreatic fibrosis.