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Christian Nievera
Researcher at Sigma-Aldrich
Publications - 2
Citations - 186
Christian Nievera is an academic researcher from Sigma-Aldrich. The author has contributed to research in topics: Chromatin remodeling & Histone methylation. The author has an hindex of 1, co-authored 2 publications receiving 160 citations.
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Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors.
Elizabeth A. Heller,Hannah M. Cates,Catherine Jensen Pena,HaoSheng Sun,Ning-Yi Shao,Jian Feng,Sam A. Golden,James P. Herman,Jessica J. Walsh,Michelle S. Mazei-Robison,Deveroux Ferguson,Scott W. Knight,Mark A. Gerber,Christian Nievera,Ming-Hu Han,Scott J. Russo,Carol S. Tamminga,Rachael L. Neve,Li Shen,H. Steve Zhang,Feng Zhang,Feng Zhang,Eric J. Nestler +22 more
TL;DR: In this article, the authors investigated the mechanism linking chromatin dynamics to neurobiological phenomena by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo, and found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses via interactions with the endogenous transcriptional machinery.
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
HaoSheng Sun,Ning-Yi Shao,Jian Feng,Michelle S. Mazei-Robison,Deveroux Ferguson,Scott W. Knight,Christian Nievera,Ming-Hu Han,Li Shen,H. Steve Zhang,Feng Zhang,Eric J. Nestler,Elizabeth A. Heller,Hannah M. Cates,Catherine Jensen Pena,Sam A. Golden,James P. Herman,Jessica J. Walsh,Mark A. Gerber,Scott J. Russo,Carol S. Tamminga,Rachael L. Neve +21 more
TL;DR: The mechanism linking chromatin dynamics to neurobiological phenomena is investigated by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo and it is found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses.