S
Scott J. Russo
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 238
Citations - 29343
Scott J. Russo is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Nucleus accumbens & Social defeat. The author has an hindex of 74, co-authored 207 publications receiving 24108 citations. Previous affiliations of Scott J. Russo include University of Pennsylvania & Allen Institute for Brain Science.
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Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Vaishnav Krishnan,Ming-Hu Han,Danielle Graham,Olivier Berton,William Renthal,Scott J. Russo,Quincey LaPlant,Ami Graham,Michael Lutter,Diane C. Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A. Green,Rachael L. Neve,Sumana Chakravarty,Arvind Kumar,Amelia J. Eisch,David W. Self,Francis S. Lee,Carol A. Tamminga,Donald C. Cooper,Howard K. Gershenfeld,Eric J. Nestler +23 more
TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.
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The brain reward circuitry in mood disorders
Scott J. Russo,Eric J. Nestler +1 more
TL;DR: This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression, and discusses some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
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A standardized protocol for repeated social defeat stress in mice
TL;DR: A protocol whereby C57BL/6J mice that are repeatedly subjected to bouts of social defeat by a larger and aggressive CD-1 mouse results in the development of a clear depressive-like syndrome, characterized by enduring deficits in social interactions.
Journal ArticleDOI
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Dipesh Chaudhury,Jessica J. Walsh,Allyson K. Friedman,Barbara Juarez,Stacy M. Ku,Ja Wook Koo,Deveroux Ferguson,Hsing-Chen Tsai,Lisa E. Pomeranz,Daniel J. Christoffel,Alexander R. Nectow,Mats I. Ekstrand,Ana Domingos,Michelle S. Mazei-Robison,Ezekiell Mouzon,Mary Kay Lobo,Rachael L. Neve,Jeffrey M. Friedman,Scott J. Russo,Karl Deisseroth,Eric J. Nestler,Ming-Hu Han +21 more
TL;DR: It is shown that optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons of mice undergoing a subthreshold social-defeat paradigm rapidly induced a susceptible phenotype as measured by social avoidance and decreased sucrose preference, which reveals novel firing-pattern- and neural-circuit-specific mechanisms of depression.