抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

This paper reviews recent experimental and theoretical progress concerning many-body phenomena in dilute, ultracold gases. It focuses on effects beyond standard weak-coupling descriptions, such as the Mott-Hubbard transition in optical lattices, strongly interacting gases in one and two dimensions, or lowest-Landau-level physics in quasi-two-dimensional gases in fast rotation. Strong correlations in fermionic gases are discussed in optical lattices or near-Feshbach resonances in the BCS-BEC crossover.

/pdf/many-body-physics-with-ultracold-gases-552s10zfdn.pdf

Many-Body Physics with Ultracold Gases

Bose-Einstein condensation (BEC) has been observed in a dilute gas of sodium atoms. A Bose-Einstein condensate consists of a macroscopic population of the ground state of the system, and is a coherent state of matter. In an ideal gas, this phase transition is purely quantum-statistical. The study of BEC in weakly interacting systems which can be controlled and observed with precision holds the promise of revealing new macroscopic quantum phenomena that can be understood from first principles.

Bose-Einstein condensation in a gas of sodium atoms

Feshbach resonances are the essential tool to control the interaction between atoms in ultracold quantum gases. They have found numerous experimental applications, opening up the way to important breakthroughs. This review broadly covers the phenomenon of Feshbach resonances in ultracold gases and their main applications. This includes the theoretical background and models for the description of Feshbach resonances, the experimental methods to find and characterize the resonances, a discussion of the main properties of resonances in various atomic species and mixed atomic species systems, and an overview of key experiments with atomic Bose-Einstein condensates, degenerate Fermi gases, and ultracold molecules.

Feshbach resonances in ultracold gases

Control over physical systems at the quantum level is important in fields as diverse as metrology, information processing, simulation and chemistry. For trapped atomic ions, the quantized motional and internal degrees of freedom can be coherently manipulated with laser light. Similar control is difficult to achieve with radio-frequency or microwave radiation: the essential coupling between internal degrees of freedom and motion requires significant field changes over the extent of the atoms' motion, but such changes are negligible at these frequencies for freely propagating fields. An exception is in the near field of microwave currents in structures smaller than the free-space wavelength, where stronger gradients can be generated. Here we first manipulate coherently (on timescales of 20 nanoseconds) the internal quantum states of ions held in a microfabricated trap. The controlling magnetic fields are generated by microwave currents in electrodes that are integrated into the trap structure. We also generate entanglement between the internal degrees of freedom of two atoms with a gate operation suitable for general quantum computation; the entangled state has a fidelity of 0.76(3), where the uncertainty denotes standard error of the mean. Our approach, which involves integrating the quantum control mechanism into the trapping device in a scalable manner, could be applied to quantum information processing, simulation and spectroscopy.

/pdf/microwave-quantum-logic-gates-for-trapped-ions-47hvenmuaz.pdf

Microwave quantum logic gates for trapped ions

We report on the creation of ultracold heteronuclear molecules assembled from fermionic {sup 40}K and bosonic {sup 87}Rb atoms in a 3D optical lattice. Molecules are produced at a heteronuclear Feshbach resonance on both the attractive and the repulsive sides of the resonance. We precisely determine the binding energy of the heteronuclear molecules from rf spectroscopy across the Feshbach resonance. We characterize the lifetime of the molecular sample as a function of magnetic field and measure lifetimes between 20 and 120 ms. The efficiency of molecule creation via rf association is measured and is found to decrease as expected for more deeply bound molecules.

https://arxiv.org/pdf/cond-mat/0607581.pdf

Ultracold heteronuclear molecules in a 3D optical lattice.

We observe a localized phase of ultracold bosonic quantum gases in a 3-dimensional optical lattice induced by a small contribution of fermionic atoms acting as impurities in a Fermi-Bose quantum gas mixture. In particular, we study the dependence of this transition on the fermionic (40)K impurity concentration by a comparison to the corresponding superfluid to Mott-insulator transition in a pure bosonic (87)Rb gas and find a significant shift in the transition parameter. The observed shift is larger than expected based on a simple mean-field argument, which indicates that disorder-related effects play a significant role.

Localization of bosonic atoms by fermionic impurities in a three-dimensional optical lattice.

The harmonic oscillator is a simple and ubiquitous physical system, and various oscillators functioning at the quantum mechanical level are known. Previously, linkage between two quantum mechanical oscillators has been achieved only indirectly, but two groups now demonstrate direct coupling at the quantum level between two harmonic oscillators in separate locations. Such systems could be used as the building blocks for quantum information processors and simulators. Brown et al. achieve direct controllable coupling between 9Be+ ions held 40 micrometres apart in trapping potentials. In a similar experiment, Harlander et al. couple single 40Ca+ ions trapped 54 μm apart. In their system, additional ions act as antennae to amplify the coupling. The harmonic oscillator is a simple and ubiquitous physical system. This paper reports a new realization in the quantum regime, achieving direct controllable coupling between quantized mechanical oscillators. The oscillators are ions held in trapping potentials (separated by 40 micrometres) and coupled through their mutual Coulomb interaction. The system could be used as a building block for quantum computers and simulators. The harmonic oscillator is one of the simplest physical systems but also one of the most fundamental. It is ubiquitous in nature, often serving as an approximation for a more complicated system or as a building block in larger models. Realizations of harmonic oscillators in the quantum regime include electromagnetic fields in a cavity1,2,3 and the mechanical modes of a trapped atom4 or macroscopic solid5. Quantized interaction between two motional modes of an individual trapped ion has been achieved by coupling through optical fields6, and entangled motion of two ions in separate locations has been accomplished indirectly through their internal states7. However, direct controllable coupling between quantized mechanical oscillators held in separate locations has not been realized previously. Here we implement such coupling through the mutual Coulomb interaction of two ions held in trapping potentials separated by 40 μm (similar work is reported in a related paper8). By tuning the confining wells into resonance, energy is exchanged between the ions at the quantum level, establishing that direct coherent motional coupling is possible for separately trapped ions. The system demonstrates a building block for quantum information processing and quantum simulation. More broadly, this work is a natural precursor to experiments in hybrid quantum systems, such as coupling a trapped ion to a quantized macroscopic mechanical or electrical oscillator9,10,11,12,13.

/pdf/coupled-quantized-mechanical-oscillators-5d6cv292fg.pdf

Coupled quantized mechanical oscillators

With a ${}^{9}{\mathrm{Be}}^{+}$ trapped-ion hyperfine-state qubit, we demonstrate an error probability per randomized single-qubit gate of $2.0(2)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$, below the threshold estimate of ${10}^{\ensuremath{-}4}$ commonly considered sufficient for fault-tolerant quantum computing. The ${}^{9}{\mathrm{Be}}^{+}$ ion is trapped above a microfabricated surface-electrode ion trap and is manipulated with microwaves applied to a trap electrode. The achievement of low single-qubit-gate errors is an essential step toward the construction of a scalable quantum computer.

/pdf/single-qubit-gate-error-below-10-4-in-a-trapped-ion-4n4cmmwkjz.pdf

Christian Ospelkaus

Papers

Microwave quantum logic gates for trapped ions

Ultracold heteronuclear molecules in a 3D optical lattice.

Localization of bosonic atoms by fermionic impurities in a three-dimensional optical lattice.

Coupled quantized mechanical oscillators

Single-qubit-gate error below 10 − 4 in a trapped ion