Christiana Winkler

TL;DR: IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryPTophan catabolites.

TL;DR: Monitoring tryptophan metabolism in chronic immunopathology provides a better understanding of the association between immune activation and IDO and its role in the development of immunodeficiency, anemia and mood disorders.

TL;DR: Low serum tryptophan concentrations and elevated serum neopterin levels can be used as predictive markers for the future course in melanoma patients, and support previous speculations that a higher degree of IDO expression could play a crucial role for tumor progression.

TL;DR: Interferon-γ appears to be a central player in atherogenesis and in the development and progression of cardiovascular disease, and associations between moderate hyperhomocysteinaemia and cellular immune activation are found in several diseases, and data indicate that hyper Homocysteine accumulation in the blood is established as an independent risk factor for cardiovascular disease.

TL;DR: Kyn/trp correlated significantly with neopterin suggesting an IFN- γ -induced increase in IDO activity, which might offer a novel non-invasive means of immunomonitoring of renal allografts.