E
Ernst R. Werner
Researcher at Innsbruck Medical University
Publications - 310
Citations - 16774
Ernst R. Werner is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Neopterin & Tetrahydrobiopterin. The author has an hindex of 67, co-authored 305 publications receiving 15982 citations. Previous affiliations of Ernst R. Werner include Washington University in St. Louis & University of Graz.
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Journal ArticleDOI
Neopterin as a marker for activated cell-mediated immunity: Application in HIV infection
Dietmar Fuchs,Arno Hausen,Gilbert Reibnegger,Ernst R. Werner,Manfred P. Dierich,Helmut Wachter +5 more
TL;DR: Neopterin studies reveal that preactivation of cell-mediated immunity is associated with poor prognosis in cancer patients and in human immunodeficiency virus infection, neopterin levels increase in parallel with progressive disease, are inversely correlated with CD4 + /CD8 + T-cell subset ratios and are of predictive significance.
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Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.
Gerald Brandacher,Alexander Perathoner,Ruth Ladurner,Ruth Ladurner,Stefan Schneeberger,Peter Obrist,Christiana Winkler,Ernst R. Werner,Gabriele Werner-Felmayer,Helmut Weiss,Georg Göbel,Raimund Margreiter,Alfred Königsrainer,Alfred Königsrainer,Dietmar Fuchs,Albert Amberger +15 more
TL;DR: IDO-high expression by colorectal tumor cells enables certain cancer subsets to initially avoid immune attack and defeat the invasion of T cells via local tryptophan depletion and the production of proapoptotic tryPTophan catabolites.
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Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase
Bernd Mayer,M. John,Burghard Heinzel,Ernst R. Werner,Helmut Wachter,Günter Schultz,Eycke Böhme +6 more
TL;DR: It is found that purified NO synthase contains enzyme‐bound H4 biopterin, explaining the enzymatic activity observed in the absence of added cofactor, and these results indicate that No synthase essentially depends on H4Biopterin as a cofactor which is recycled during enzymatically NO formation.
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Iron regulates nitric oxide synthase activity by controlling nuclear transcription.
Gtinter Weiss,Gabriele Werner-Felmayer,Ernst R. Werner,Kurt Grünewald,Helmut Wachter,Matthias W. Hentze +5 more
TL;DR: The results suggest the existence of a regulatory loop between iron metabolism and the NO/NOS pathway, and nuclear run-off experiments demonstrate that nuclear transcription of cytokine-inducible NOS mRNA is strongly increased by desferrioxamine whereas it is decreased by Fe(3+).
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Simultaneous measurement of serum tryptophan and kynurenine by HPLC.
TL;DR: A new HPLC method is described to determine the amounts of kynurenine and tryptophan in serum simultaneously with use of an external albumin-based calibrator and an internal calibrator, enabling indirect examination of endogenous interferon-γ formation.