C
Christina Alm
Researcher at Karolinska Institutet
Publications - 25
Citations - 2008
Christina Alm is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 21, co-authored 25 publications receiving 1955 citations. Previous affiliations of Christina Alm include University of Extremadura & Lund University.
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Journal ArticleDOI
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
Leif Bertilsson,Juan Antonio Carrillo,Marja-Liisa Dahl,Adrián LLerena,Christina Alm,U Bondesson,L Lindstrom,I Rodriguez de la Rubia,Sara I. Ramos,Julio Benítez +9 more
TL;DR: This study suggests that clozapine is metabolised by CYP1A2 to a major extent and no significant relationships with xanthine oxidase and N-acetyl transferase activity, also assessed by a caffeine test, were found.
Journal ArticleDOI
Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings
Marja-Liisa Dahl-Puustinen,Marja-Liisa Dahl-Puustinen,Anders Lidén,Anders Lidén,Christina Alm,Christina Alm,Conny Nordin,Conny Nordin,Leif Bertilsson,Leif Bertilsson +9 more
TL;DR: The pharmacokinetics of a single oral dose of 6 mg perphenazine was studied in a group of six slow and six rapid hydroxylators of debrisoquin and the data suggest that the disposition of the antipsychotic drug per phenazine covaries with polymorphic debrisOquin hydroxymation.
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Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype.
TL;DR: PM of debrisoquine (7% of Caucasian populations) might, therefore, on common doses of haloperidol, achieve high plasma concentrations and thereby have an increased risk of side effects and at the other extreme, very rapid metabolizers may need increased doses of Haloperidols.
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Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation.
TL;DR: The O-demethylation of codeine to form M appears to be under the same polymorphic genetic control as the 4-hydroxylation of debrisoquine.
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S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin.
TL;DR: Coadministration of debrisoquin and mephenytoin before bedtime and urine collection during two consecutive nights allow for an accurate determination of both phenotypes in the population.