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Adrián LLerena
Researcher at University of Extremadura
Publications - 237
Citations - 7060
Adrián LLerena is an academic researcher from University of Extremadura. The author has contributed to research in topics: Population & Pharmacogenetics. The author has an hindex of 43, co-authored 226 publications receiving 6276 citations. Previous affiliations of Adrián LLerena include Karolinska Institutet & Carlos III Health Institute.
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Journal ArticleDOI
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors
JK Hicks,Jeffrey R. Bishop,Katrin Sangkuhl,Daniel J. Müller,Yuan Ji,SG Leckband,J. S. Leeder,Rebecca L. Graham,DL Chiulli,Adrián LLerena,Todd C. Skaar,Stuart A. Scott,Julia C. Stingl,Teri E. Klein,Kelly E. Caudle,Andrea Gaedigk +15 more
TL;DR: Evidence from the published literature supporting associations between CYP2D6 and CYC19 polymorphisms and SSRIs efficacy and safety is summarized and dosing recommendations for fluvoxamine, paroxetine, citalopram, escitaloprams, and sertraline based on CYP1C19 genotype are provided.
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Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
Leif Bertilsson,Juan Antonio Carrillo,Marja-Liisa Dahl,Adrián LLerena,Christina Alm,U Bondesson,L Lindstrom,I Rodriguez de la Rubia,Sara I. Ramos,Julio Benítez +9 more
TL;DR: This study suggests that clozapine is metabolised by CYP1A2 to a major extent and no significant relationships with xanthine oxidase and N-acetyl transferase activity, also assessed by a caffeine test, were found.
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Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype.
Umit Yasar,Umit Yasar,Cecilia Forslund-Bergengren,Cecilia Forslund-Bergengren,Gunnel Tybring,Gunnel Tybring,Pedro Dorado,Pedro Dorado,Adrián LLerena,Adrián LLerena,Folke Sjöqvist,Folke Sjöqvist,Erik Eliasson,Erik Eliasson,Marja-Liisa Dahl,Marja-Liisa Dahl +15 more
TL;DR: The aim was to evaluate the pharmacokinetics of losartan and E‐3174 in relation to the CYP2C9 genotype.
Journal ArticleDOI
Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype.
TL;DR: PM of debrisoquine (7% of Caucasian populations) might, therefore, on common doses of haloperidol, achieve high plasma concentrations and thereby have an increased risk of side effects and at the other extreme, very rapid metabolizers may need increased doses of Haloperidols.
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Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6.
TL;DR: There may be a relationship between personality and the activity of the enzyme hydroxylating debrisoquine (cytochrome P4502D6), which may have an endogenous neuroactive substrate or product, such as a biogenic neurotransmitter amine.