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Christina L. L. Chai
Researcher at National University of Singapore
Publications - 189
Citations - 3884
Christina L. L. Chai is an academic researcher from National University of Singapore. The author has contributed to research in topics: Catalysis & Radical polymerization. The author has an hindex of 31, co-authored 184 publications receiving 3470 citations. Previous affiliations of Christina L. L. Chai include Centre for Life & International Council for the Exploration of the Sea.
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Journal ArticleDOI
Copper-catalyzed oxidative amidation of aldehydes with amine salts: synthesis of primary, secondary, and tertiary amides.
Subhash Chandra Ghosh,Joyce S. Y. Ngiam,Abdul Majeed Seayad,Dang Thanh Tuan,Christina L. L. Chai,Anqi Chen +5 more
TL;DR: A practical method for the amidation of aldehydes with economic ammonium chloride or amine hydrochloride salts has been developed and has been demonstrated in an efficient synthesis of the antiarrhythmic drug N-acetylprocainamide.
Journal ArticleDOI
Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing.
David P. Fairlie,Joel D. A. Tyndall,Robert Reid,Allan Wong,Giovanni Abbenante,Martin J. Scanlon,Darren R. March,Douglas A. Bergman,Christina L. L. Chai,Brendan A. Burkett +9 more
TL;DR: Conformational selection explains the resistance of folded/structured regions of proteins to proteolytic degradation, the susceptibility of denatured proteins to processing, and the higher affinity of conformationally constrained 'extended' inhibitors/substrates for proteases.
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Iron-Catalyzed Efficient Synthesis of Amides from Aldehydes and Amine Hydrochloride Salts
Subhash Chandra Ghosh,Joyce S. Y. Ngiam,Christina L. L. Chai,Abdul Majeed Seayad,Tuan Thanh Dang,Anqi Chen +5 more
TL;DR: The application of this novel amide formation reaction to the synthesis of pharmaceuti- cal compounds has been successfully demonstrated and a wide range of amides have been obtained under mild conditions.
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Iron-Catalysed sp3–sp3 Cross-Coupling Reactions of Unactivated Alkyl Halides with Alkyl Grignard Reagents
TL;DR: In this article, an iron-catalysed sp 3 -sp 3 Kumada coupling with primary and secondary alkyl halides and Grignard reagents has been achieved in low to good yields depending on the nature of the R group.
Journal ArticleDOI
Structure−Activity Relationship Studies of Phenanthridine-Based Bcl-XL Inhibitors
Paul H. Bernardo,Kah-Fei Wan,Thirunavukkarasu Sivaraman,Jin Xu,Felicity K. Moore,Alvin W. Hung,Henry Y. K. Mok,Victor C. Yu,Christina L. L. Chai +8 more
TL;DR: The synthesis of phenanthridine-based analogues of the natural products that were used to probe the difference in binding profiles were detailed, which identified the structural motifs required for binding-site specificity as well as inhibitory activity.