Showing papers by "Christina Wang published in 1985"

Association of HLA antigens with thyrotoxic Graves' disease and periodic paralysis in Hong Kong Chinese.

Abstract: SUMMARY The HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves’ disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 110 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased in patients with Graves’ disease and with periodic paralysis. The prevalence of DRw9 was also slightly increased but not at a statistically significant level. The high prevalence of Bw46 related to patients with early age at onset whereas patients with later age at onset had a significantly increased prevalence of HLA B5. It is suggested that Graves’ disease in Chinese is due to two HLA-associated mechanisms in which early-onset disease is associated with Bw46 and late-onset disease with B5.

Cross-sectional study of semen parameters in a large group of normal Chinese men.

Abstract: Testicular size, semen characteristics and serum reproductive hormone levels were studied in 1239 normal Chinese men. The mean testicular size of 17 ml in this group of subjects was similar to other reports in Orientals but was smaller than that reported in Caucasians. Semen volume, and the sperm count, motility and morphology were comparable to those described for Caucasian subjects. The cervical mucus penetration test (Kremer's test) and the zona-free hamster egg penetration test were also studied in some of the subjects. Age showed a positive correlation with the serum levels of FSH and LH, which were highly correlated with each other. Sperm concentration and the total sperm count were positively correlated with testicular volume, the length of abstinence, the % of sperm with an oval head, and the zona-free hamster egg penetration test, but were negatively correlated with serum FSH. Sperm motility was negatively correlated with the duration of abstinence but was positively correlated with the % normal sperm. The results constitute a normal data base from Chinese men for comparison with studies in male infertility and fertility regulation.

Analysis of linkage between HLA haplotype and susceptibility to Graves' disease in multiple-case Chinese families in Hong Kong.

Abstract: Data from 10 Chinese families in Hong Kong with multiple cases of thyrotoxic Graves' disease were analysed to determine whether genes predisposing to Graves' disease are linked to the HLA region No evidence was obtained in favour of either dominant or recessive inheritance of HLA-linked susceptibility to Graves' disease Six of 10 affected parent-offspring combinations had haplotypes containing HLA Bw46 which is more than would be expected from the antigen frequency of Bw46 in normal controls It is concluded that HLA-associated genes play a role in determining disease susceptibility but that other factors are involved in determining disease expression

Primary hypothyroidism and essential hypernatremia in a patient with histiocytosis X.

Abstract: :A 27 year old woman with histiocytosis X had an unusual initial presentation with features of primary hypothyroidism and a goitre. Diagnosis was made by lung and thyroid biopsies. Endocrine tests showed the presence of hypopituitarism and a discrete suprasellar mass, consistent with hypothalamic histiocytosis X, was demonstrated by computerised tomography. Radiotherapy and chemotherapy arrested the clinical progression of the disease.