C
Christine A Houlihan
Researcher at Mercy Hospital for Women
Publications - 27
Citations - 830
Christine A Houlihan is an academic researcher from Mercy Hospital for Women. The author has contributed to research in topics: Pregnancy & Diabetes mellitus. The author has an hindex of 14, co-authored 27 publications receiving 735 citations. Previous affiliations of Christine A Houlihan include University of Melbourne & Austin Hospital.
Papers
More filters
Journal ArticleDOI
Albuminuria in patients with type 1 diabetes is directly linked to changes in the lysosome-mediated degradation of albumin during renal passage.
TL;DR: Whether albumin is metabolized during renal passage in nondiabetic volunteers and in type 1 diabetic patients with varying levels of albuminuria is examined, and the degradation process is inhibited in diabetic nephropathy in proportion to the level ofalbuminuria detected by RIA.
Journal ArticleDOI
A Low-Sodium Diet Potentiates the Effects of Losartan in Type 2 Diabetes
Christine A Houlihan,Terri J. Allen,Amynta L. Baxter,Sianna Panangiotopoulos,David J. Casley,Mark E. Cooper,George Jerums +6 more
TL;DR: It is demonstrated that a low-sodium diet potentiates the antihypertensive and antiproteinuric effects of losartan in type 2 diabetes.
Journal ArticleDOI
Albumin to creatinine ratio: a screening test with limitations.
TL;DR: Spot ACR is a good screening test for microalbuminuria, but a poor predictor of quantitative AER, and should not be used as a diagnostic test, and the increase in spot ACR relative to 24-hour AER with age supports the use of sex- and age-adjusted ACR cutoff values.
Journal ArticleDOI
Urinary Transforming Growth Factor-β Excretion in Patients With Hypertension, Type 2 Diabetes, and Elevated Albumin Excretion Rate: Effects of angiotensin receptor blockade and sodium restriction
Christine A Houlihan,Aysel Akdeniz,Con Tsalamandris,Mark E. Cooper,George Jerums,Richard E. Gilbert +5 more
TL;DR: In hypertensive type 2 diabetic patients with elevated AER, the ARB losartan, but not sodium restriction, reduced urinary TGF-beta excretion is suggested, suggesting that the renoprotective effects ofLosartan in patients with type 2 diabetes and nephropathy may include a reduction in renal TGF -beta production.
Journal ArticleDOI
Effects of Salt Supplementation on the Albuminuric Response to Telmisartan With or Without Hydrochlorothiazide Therapy in Hypertensive Patients With Type 2 Diabetes Are Modulated by Habitual Dietary Salt Intake
Elif I Ekinci,Georgina Thomas,David P. Thomas,Cameron Johnson,Richard J MacIsaac,Christine A Houlihan,Sue Finch,Sianna Panagiotopoulos,Christopher O'Callaghan,George Jerums +9 more
TL;DR: The AER response to telmisartan with or without HCT under habitual low salt intake can be blunted by NaCl supplementation, but when there is already a suppressed renin angiotensin aldosterone system under habitual high dietary salt intake, the additional NaCl does not alter the A ER response.