C
Christine Del-Carmen
Researcher at Pfizer
Publications - 1
Citations - 55
Christine Del-Carmen is an academic researcher from Pfizer. The author has an hindex of 1, co-authored 1 publications receiving 52 citations.
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Discovery of pyrroloaminopyrazoles as novel PAK inhibitors.
Chuangxing Guo,Indrawan James Mcalpine,Zhang Junhu,Daniel D. Knighton,Kephart Susan Elizabeth,M. Catherine Johnson,Li Haitao,Djamal Bouzida,Yang Anle,Dong Liming,Marakovits Joseph T,Tikhe Jayashree Girish,Paul G. Richardson,Lisa C. Guo,Robert Steven Kania,Martin Paul Edwards,Eugenia Kraynov,James G. Christensen,Joseph Piraino,Joseph K. T. Lee,Eleanor Dagostino,Christine Del-Carmen,Ya-Li Deng,Tod Smeal,Brion W. Murray +24 more
TL;DR: The efflux of the pyrrolopyrazole series was effectively reduced by applying multiple medicinal chemistry strategies, leading to a series of PAK inhibitors that are orally active in inhibiting tumor growth in vivo.