C
Christine Lange Cannova
Researcher at Merck & Co.
Publications - 5
Citations - 692
Christine Lange Cannova is an academic researcher from Merck & Co.. The author has contributed to research in topics: Histone deacetylase & Apicidin. The author has an hindex of 4, co-authored 5 publications receiving 657 citations.
Papers
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Journal ArticleDOI
Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase
Sandra J. Darkin-Rattray,Anne Gurnett,Robert W. Myers,Paula M. Dulski,Tami Crumley,John J. Allocco,Christine Lange Cannova,Peter T. Meinke,Steven L. Colletti,Maria A. Bednarek,Sheo B. Singh,Michael A. Goetz,Anne W. Dombrowski,Jon D. Polishook,Dennis M. Schmatz +14 more
TL;DR: A novel fungal metabolite, apicidin, that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified and is also orally and parenterally active in vivo against Plasmodium berghei malaria in mice.
Journal ArticleDOI
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Steven L. Colletti,Robert W. Myers,Sandra J. Darkin-Rattray,Anne Gurnett,Paula M. Dulski,Stefan Galuska,John J. Allocco,Michelle B. Ayer,Chunshi Li,Julie Lim,Tami Crumley,Christine Lange Cannova,Dennis M. Schmatz,Matthew J. Wyvratt,Michael H. Fisher,Peter T. Meinke +15 more
TL;DR: The conversion of apicidin, a nonselective nanomolar inhibitor of HDACs, into a series of picomolar indole-modified and parasite-selective tryptophan-replacement analogues is described within this structure-activity study.
Journal ArticleDOI
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1
Steven L. Colletti,Robert W. Myers,Sandra J. Darkin-Rattray,Anne Gurnett,Paula M. Dulski,Stefan Galuska,John J. Allocco,Michelle B. Ayer,Chunshi Li,Julie Lim,Tami Crumley,Christine Lange Cannova,Dennis M. Schmatz,Matthew J. Wyvratt,Michael H. Fisher,Peter T. Meinke +15 more
TL;DR: The conversion of apicidin, a nanomolar inhibitor of HDACs, into a series of side-chain analogues that display picomolar enzyme affinity is described within this structure-activity study.
Patent
Antiprotozoal cyclic tetrapeptides
Christine Lange Cannova,Anne W. Dombrowski,Michael A. Goetz,Rattray Sandra J,Sheo B. Singh,Jon D. Polishook,Gerald F. Bills,Joyce A. Greene,Gary Darland +8 more
TL;DR: In this article, the authors presented cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.