J
John J. Allocco
Researcher at Merck & Co.
Publications - 19
Citations - 2264
John J. Allocco is an academic researcher from Merck & Co.. The author has contributed to research in topics: Histone deacetylase & Apicidin. The author has an hindex of 16, co-authored 19 publications receiving 2116 citations.
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Journal ArticleDOI
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang,Stephen M. Soisson,Katherine Young,Wesley L. Shoop,Wesley L. Shoop,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Gopalakrishnan Parthasarathy,Yui S. Tang,Richard D. Cummings,Sookhee Ha,Karen Dorso,Mary Motyl,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Lorraine D. Hernandez,John J. Allocco,Angela Basilio,José R. Tormo,Olga Genilloud,Francisca Vicente,Fernando Pelaez,Lawrence F. Colwell,Sang Ho Lee,B.F. Michael,Thomas J. Felcetto,Charles Gill,Lynn L. Silver,Lynn L. Silver,Jeffery D. Hermes,Ken Bartizal,John F. Barrett,Dennis M. Schmatz,Joseph W. Becker,Doris F. Cully,Sheo B. Singh +38 more
TL;DR: Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Journal ArticleDOI
Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase
Sandra J. Darkin-Rattray,Anne Gurnett,Robert W. Myers,Paula M. Dulski,Tami Crumley,John J. Allocco,Christine Lange Cannova,Peter T. Meinke,Steven L. Colletti,Maria A. Bednarek,Sheo B. Singh,Michael A. Goetz,Anne W. Dombrowski,Jon D. Polishook,Dennis M. Schmatz +14 more
TL;DR: A novel fungal metabolite, apicidin, that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified and is also orally and parenterally active in vivo against Plasmodium berghei malaria in mice.
Journal ArticleDOI
Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase
Robert G. K. Donald,John J. Allocco,Suresh B. Singh,Bakela Nare,Scott P. Salowe,Judyann Wiltsie,Paul A. Liberator +6 more
TL;DR: The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models.
Journal ArticleDOI
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
John W. Phillips,Michael A. Goetz,Scott K. Smith,Deborah L. Zink,Jon D. Polishook,Russell Onishi,Scott P. Salowe,Judyann Wiltsie,John J. Allocco,Janet M. Sigmund,Karen Dorso,Suzy Lee,Stephen Skwish,Mercedes de la Cruz,Jesús Martín,Francisca Vicente,Olga Genilloud,Jun Lu,Ronald E. Painter,Katherine Young,Karen M. Overbye,Robert G. K. Donald,Sheo B. Singh +22 more
TL;DR: Kibdelomycin is the first truly novel bacterial type II topoisomerase inhibitor with potent antibacterial activity discovered from natural product sources in more than six decades.
Journal ArticleDOI
Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase.
Robert G. K. Donald,Tanya Zhong,Helen I Wiersma,Bakela Nare,Dan Yao,Anita Lee,John J. Allocco,Paul A. Liberator +7 more
TL;DR: Results provide an example of the utility of the Toxoplasma model system for investigating the mechanism of action of novel anticoccidial agents and suggest a role for additional secondary protein kinase targets.