C
Christine M. Cunningham
Researcher at University of California, Los Angeles
Publications - 18
Citations - 675
Christine M. Cunningham is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Pulmonary hypertension & Lung. The author has an hindex of 8, co-authored 16 publications receiving 381 citations.
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Journal ArticleDOI
The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy.
Andrea Iorga,Christine M. Cunningham,Shayan Moazeni,Gregoire Ruffenach,Soban Umar,Mansoureh Eghbali +5 more
TL;DR: The controversies surrounding the clinical use of exogenous E2 as a therapeutic agent for cardiovascular disease in women due to the possible risks of thrombotic events, cancers, and arrhythmia are discussed.
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Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
Dawoud Sulaiman,Jingyuan Li,Asokan Devarajan,Christine M. Cunningham,Min Li,Gregory A. Fishbein,Alan M. Fogelman,Mansoureh Eghbali,Srinivasa T. Reddy +8 more
TL;DR: PON2 protects against acute myocardial IRI by reducing mitochondrial dysfunction and oxidative stress in cardiomyocytes via activation of the PI3K/Akt/GSK-3β RISK pathway.
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The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension.
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Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19.
Lejla Medzikovic,Christine M. Cunningham,Min Li,Marjan Amjedi,Jason S. Hong,Gregoire Ruffenach,Mansoureh Eghbali +6 more
TL;DR: A basic science perspective on current clinical observations in this rapidly evolving field is provided and the interplay sex differences, preexisting CVD and COVID-19-related cardiac injury is discussed.
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Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning.
Jason Hong,Douglas Arneson,Soban Umar,Gregoire Ruffenach,Christine M. Cunningham,In Sook Ahn,Graciel Diamante,May Bhetraratana,John F. Park,Emma Said,Caroline Huynh,Trixie Le,Lejla Medzikovic,Marc Humbert,Florent Soubrier,David Montani,Barbara Girerd,David-Alexandre Trégouët,Richard N. Channick,Rajan Saggar,Mansoureh Eghbali,Xia Yang +21 more
TL;DR: This study revealed the distinct and shared dysregulation of genes and pathways in two commonly used PAH models for the first time at single-cell resolution and demonstrated their relevance to human PAH and utility for drug repositioning.