Christine T. Ekdahl

TL;DR: It is demonstrated that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats, raising the possibility that suppression of hippocampal Neurogenesis by activatedmicroglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.

TL;DR: It is concluded that microglia activation, as an indicator of inflammation, is not pro- or antineurogenic per se but the net outcome is dependent on the balance between secreted molecules with pro- and antiinflammatory action.

TL;DR: It is shown that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self‐repair strategies to improve recovery after stroke.

TL;DR: In this paper, the TNF-R1 and its receptors play any role for neurogenesis in the adult brain and are found to be a negative regulator of neural progenitor proliferation in both intact and pathological brain.

TL;DR: Increased numbers of activated microglia in ipsilateral SVZ concomitant with neuroblast migration into the striatum are demonstrated at 2, 6, and 16 weeks, with maximum at 6 weeks, following 2 h middle cerebral artery occlusion in rats.