C
Christine Wai
Researcher at University of North Carolina at Chapel Hill
Publications - 20
Citations - 489
Christine Wai is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Protein kinase B & Osteoclast. The author has an hindex of 12, co-authored 18 publications receiving 421 citations.
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Insulin-Like Growth Factor (IGF) Binding Protein 2 Functions Coordinately with Receptor Protein Tyrosine Phosphatase β and the IGF-I Receptor To Regulate IGF-I-Stimulated Signaling
TL;DR: Analysis of aortas obtained from IGFBP-2−/− mice showed that RPTPβ was activated, and this was associated with inhibition of IGF-I stimulated AKT Ser473 phosphorylation and VSMC proliferation, and changes were rescued following administration of IGF BP-2.
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Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells
TL;DR: Nox4-derived ROS is responsible for the enhancing effect of hyperglycemia on IGF-I–stimulated Src activation, which in turn amplifies IGF- I–linked downstream signaling and biological actions.
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IGFBP‐2 Directly Stimulates Osteoblast Differentiation
TL;DR: It is shown that stimulation of differentiation is an important mechanism by which IGFBP‐2 regulates the acquisition of normal bone mass in mice and that this effect is mediated through its heparin‐binding domain‐1 interacting with RPTPβ.
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Recruitment of Nox4 to a Plasma Membrane Scaffold Is Required for Localized Reactive Oxygen Species Generation and Sustained Src Activation in Response to Insulin-like Growth Factor-I
TL;DR: Insight is provided into the mechanism by which localized Nox4-derived ROS regulates the sustained activity of a tyrosine kinase that is critical for mediating signal transduction and biological actions.
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Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation.
Victoria E. DeMambro,Laura A. Maile,Christine Wai,Masanobu Kawai,Teresa Cascella,Clifford J. Rosen,David R. Clemmons +6 more
TL;DR: It is concluded that IGF BP‐2 is an important regulator of osteoclastogenesis and that both the heparin‐ and the IGF‐binding domains of IGFBP‐2 are essential for the formation of fully differentiated and functional osteoclasts.