C
Christine Yueh
Researcher at Boston University
Publications - 8
Citations - 2304
Christine Yueh is an academic researcher from Boston University. The author has contributed to research in topics: Binding site & Druggability. The author has an hindex of 7, co-authored 8 publications receiving 1416 citations.
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Journal ArticleDOI
The ClusPro web server for protein-protein docking.
Dima Kozakov,David R. Hall,Bing Xia,Kathryn A. Porter,Dzmitry Padhorny,Christine Yueh,Dmitri Beglov,Sandor Vajda +7 more
TL;DR: This protocol describes the use of the various options, the construction of auxiliary restraints files, the selection of the energy parameters, and the analysis of the results of the ClusPro server.
Journal ArticleDOI
New additions to the ClusPro server motivated by CAPRI.
Sandor Vajda,Christine Yueh,Dmitri Beglov,Tanggis Bohnuud,Scott E. Mottarella,Bing Xia,David R. Hall,Dima Kozakov +7 more
TL;DR: An extremely fast docking algorithm based on 5D rotational manifold FFT, and an algorithm for docking flexible peptides that include known sequence motifs that will further improve the utility of ClusPro.
Journal ArticleDOI
Detection of peptide‐binding sites on protein surfaces: The first step toward the modeling and targeting of peptide‐mediated interactions
Assaf Lavi,Chi Ho Ngan,Dana Movshovitz-Attias,Tanggis Bohnuud,Christine Yueh,Dmitri Beglov,Ora Schueler-Furman,Dima Kozakov +7 more
TL;DR: The PeptiMap protocol, a protocol for the accurate mapping of peptide binding sites on protein structures, is presented, based on experimental evidence that peptide‐binding sites also bind small organic molecules of various shapes and polarity.
Journal ArticleDOI
New Frontiers in Druggability.
TL;DR: A computational analog of this method, based on mapping proteins using small molecules as probes, can reliably reproduce druggability results from NMR-based screening and can provide a more meaningful assessment in cases where the two approaches disagree.
Journal ArticleDOI
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases
Christine Yueh,Justin Rettenmaier,Bing Xia,David Hall,Andrey Alekseenko,Kathryn A. Porter,Krister J. Barkovich,György M. Keserü,Adrian Whitty,James A. Wells,Sandor Vajda,Dima Kozakov +11 more
TL;DR: Kinase Atlas is a systematic collection of binding hot spots located at the above ten sites in 4910 structures of 376 distinct kinases available in the Protein Data Bank, a computational analogue of experimental fragment screening.