G
György M. Keserü
Researcher at Hungarian Academy of Sciences
Publications - 124
Citations - 4160
György M. Keserü is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 28, co-authored 107 publications receiving 3571 citations. Previous affiliations of György M. Keserü include University of Florida.
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The role of ligand efficiency metrics in drug discovery
TL;DR: Optimize ligand efficiency metrics based on both molecular mass and lipophilicity, when set in the context of the specific target, has the potential to ameliorate the inflation of these properties that has been observed in current medicinal chemistry practice, and to increase the quality of drug candidates.
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Expanding the medicinal chemistry synthetic toolbox
TL;DR: Opportunities for the expansion of the medicinal chemists' synthetic toolbox are highlighted to enable enhanced impact of new methodologies in future drug discovery.
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Finding the sweet spot: the role of nature and nurture in medicinal chemistry
Michael M. Hann,György M. Keserü +1 more
TL;DR: Scientific, strategic, organizational and cultural considerations for medicinal chemistry practices are discussed, with the aim of promoting more effective use of what is already known, as well as a wider appreciation of the risks of pursuing suboptimal compounds.
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Hit discovery and hit-to-lead approaches.
TL;DR: Common industry practices adopted to tackle hit-to-lead challenges are summarized and how the advantages and drawbacks of different hit discovery techniques could affect the various issues hit- to-lead groups face are reviewed.
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Impact of Lipophilic Efficiency on Compound Quality
TL;DR: It is found that both LLE and LELP help identifying better quality compounds and monitoring lipophilic efficiency metrics could contribute significantly to compound quality and might improve the output of medicinal chemistry programs.