C
Christof Angst
Researcher at Novartis
Publications - 21
Citations - 1708
Christof Angst is an academic researcher from Novartis. The author has contributed to research in topics: NMDA receptor & Kainate receptor. The author has an hindex of 11, co-authored 20 publications receiving 1681 citations.
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Journal ArticleDOI
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Klemens Kaupmann,Katharina Huggel,Jakob Heid,Peter J. Flor,Serge Bischoff,Stuart J. Mickel,Mcmaster Gary Kent,Christof Angst,Helmut Bittiger,Wolfgang Froestl,Bernhard Bettler +10 more
TL;DR: The cloning of GABAB receptors is reported and photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system.
Journal ArticleDOI
[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain
Matthew A. Sills,Graham E. Fagg,Mario F. Pozza,Christof Angst,Derek E. Brundish,S D Hurt,E. J. Wilusz,Michael Williams +7 more
TL;DR: Results suggest that [3H]CGP 39653 selectively binds to the NMDA receptor as an antagonist with high affinity and is currently the ligand of choice for labeling theNMDA receptor.
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CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity
G.E. Fagg,H.-R. Olpe,Mario F. Pozza,J. Baud,Martin W. Steinmann,M. Schmutz,C. Portet,P. A. Baumann,K. Thedinga,Helmut Bittiger,H. Allgeier,Roland Heckendorn,Christof Angst,Derek E. Brundish,John Grey Dr Dingwall +14 more
TL;DR: CGP 37849 and CGP 39551 are potent and competitive NMDA receptor antagonists which show significant central effects following oral administration to animals and may find value as tools to elucidate the roles of NMDA receptors in brain function, and potentially as therapeutic agents for the treatment of neurological disorders such as epilepsy and ischaemic brain damage in man.
Journal ArticleDOI
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Hutchison Alan J,Michael Williams,Christof Angst,de Jesus R,L. Blanchard,R. H. Jackson,E. J. Wilusz,Deborah E. Murphy,P. S. Bernard,J. Schneider +9 more
TL;DR: A putative bioactive conformation for AP-5 is hypothesized from the SAR data presented and a preliminary model for the antagonist-preferring state of the NMDA receptor is presented.