C
Christoph D. Karp
Researcher at California Institute of Technology
Publications - 40
Citations - 2880
Christoph D. Karp is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Mixing (physics) & Communication channel. The author has an hindex of 26, co-authored 40 publications receiving 2450 citations. Previous affiliations of Christoph D. Karp include Agilent Technologies.
Papers
More filters
Journal ArticleDOI
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH
Chee-Huat Linus Eng,Michael J. Lawson,Qian Zhu,Ruben Dries,Noushin Koulena,Yodai Takei,Jina Yun,Christopher J. Cronin,Christoph D. Karp,Guo-Cheng Yuan,Long Cai +10 more
TL;DR: It is shown that seqFISH+ can image mRNAs for 10,000 genes in single cells—with high accuracy and sub-diffraction-limit resolution—in the cortex, subventricular zone and olfactory bulb of mouse brain, using a standard confocal microscope.
Journal ArticleDOI
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH
Sheel Shah,Yodai Takei,Wen Zhou,Eric Lubeck,Jina Yun,Chee Huat Linus Eng,Noushin Koulena,Christopher J. Cronin,Christoph D. Karp,Eric J. Liaw,Mina Amin,Long Cai +11 more
TL;DR: Surprisingly, the global nascent transcription oscillated asynchronously in individual cells with a period of 2 hr in mouse embryonic stem cells, as well as in fibroblasts, and reveals nuclear organizational principles and fast dynamics in single cells that are otherwise obscured.
Patent
Flow control in multi-stream microfluidic devices
TL;DR: In this paper, the authors propose a plurality of elevated flow resistance regions to promote precise and predictable splitting of an established fluidic flow through a microfluidic channel among multiple downstream microfluideic channels.
Patent
Microfluidic analytical devices and methods
Stephen D. O'Connor,Christoph D. Karp,Marci Pezzuto,Courtney Coyne,Steven E. Hobbs,Eugene Dantsker +5 more
TL;DR: Modular microfluidic systems as discussed by the authors are polymeric, stencil-based structures adapted to be coupled in sequence for performing biological or chemical synthesis, including, but not limited to, chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products.
Patent
Microfluidic synthesis devices and methods
Stephen D. O'Connor,Christoph D. Karp,Marci Pezzuto,Paren P. Patel,Steven E. Hobbs,Eugene Dantsker +5 more
TL;DR: In this article, a microfluidic reactor for performing chemical and biological synthesis reactions, including chemical syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products is provided.