C
Christophe Clec’h
Researcher at French Institute of Health and Medical Research
Publications - 44
Citations - 3812
Christophe Clec’h is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Intensive care & Intensive care unit. The author has an hindex of 29, co-authored 44 publications receiving 3441 citations. Previous affiliations of Christophe Clec’h include Paris Diderot University.
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Journal ArticleDOI
Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock: The CRISTAL Randomized Trial
Djillali Annane,Shidasp Siami,Samir Jaber,Claude Martin,Souheil Elatrous,Adrien Descorps Declère,Jean-Charles Preiser,Hervé Outin,Gilles Troché,C. Charpentier,Jean-Louis Trouillet,Antoine Kimmoun,Xavier Forceville,Michael Darmon,Olivier Lesur,Jean Régnier,Fekri Abroug,Philippe Berger,Christophe Clec’h,Joel Cousson,Laure Thibault,Sylvie Chevret +21 more
TL;DR: Within 28 days, there were 359 deaths (25.4%) in colloids group vs 390 deaths (27.0%) in crystalloids group (relative risk [RR], 0.96 [95% CI, 0.88 to 1.03]; P =.19) and there were more days alive without mechanical ventilation as discussed by the authors.
Journal ArticleDOI
Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis.
Maarten Bekaert,Jean-François Timsit,Stijn Vansteelandt,Pieter Depuydt,Aurélien Vesin,Maité Garrouste-Orgeas,Johan Decruyenaere,Christophe Clec’h,Elie Azoulay,Dominique Benoit +9 more
TL;DR: This study is the first that simultaneously accounts for the time of acquiring VAP, informative loss to follow-up after ICU discharge, and the existence of complex feedback relations between VAP and the evolution of disease severity.
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Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial.
Djillali Annane,Alain Cariou,Virginie Maxime,Elie Azoulay,Gilles Dhonneur,Jean-François Timsit,Yves Cohen,Michel Wolf,Muriel Fartoukh,Christophe Adrie,Charles Santre,Pierre Edouard Bollaert,Armelle Mathonet,Roland Amathieu,Alexis Tabah,Christophe Clec’h,Julien Mayaud,Julie Lejeune,Sylvie Chevret +18 more
TL;DR: Compared with conventional insulin therapy, intensive insulin therapy did not improve in-hospital mortality among patients who were treated with hydrocortisone for septic shock and the addition of oral fludrocort isone did not result in a statistically significant improvement in in- hospital mortality.
Journal ArticleDOI
Diagnostic and prognostic value of procalcitonin in patients with septic shock.
Christophe Clec’h,Françoise Ferriere,Philippe Karoubi,Fosse Jp,Michel Cupa,Philippe Hoang,Yves Cohen +6 more
TL;DR: These data indicate that procalcitonin may be a valuable early diagnostic and prognostic marker in patients with septic shock, and C-reactive protein was not helpful for predicting mortality.
Journal ArticleDOI
Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models
Molière Nguile-Makao,Jean-Ralph Zahar,Adrien Français,Alexis Tabah,Maité Garrouste-Orgeas,Bernard Allaouchiche,Dany Goldgran-Toledano,Elie Azoulay,Christophe Adrie,Samir Jamali,Christophe Clec’h,Bertrand Souweine,Jean-François Timsit +12 more
TL;DR: A multistate model that appropriately handled VAP as a time-dependent event produced lower VAP-AM values than conditional logistic regression, and this may contribute to the variability of previous estimates.