Christophe Penna

TL;DR: KRAS mutations are a predictor of resistance to cetuximab therapy and are associated with a worse prognosis, and the EGFR amplification, which is not as frequent as initially reported, is also associated with response to this treatment.

TL;DR: In this article, the effects of preoperative systemic chemotherapy on liver parenchyma and the consequences on postoperative mortality, morbidity, and liver function tests were analyzed. But, the authors did not investigate the effect of systemic pre-operative chemotherapy on post-operative mortality.

TL;DR: Prolonged neoadjuvant systemic chemotherapy alters liver parenchyma and increases morbidity after major resection under total hepatic vascular exclusion, but it does not increase operative mortality.

TL;DR: Overall, persistent macroscopic or microscopic residual disease or early recurrence in situ were observed in 55 (83%) of 66 LMs having a complete response on imaging.

TL;DR: A perioperative geriatric assessment should be recommended to patients with an American Society of Anesthesiologists status of 3–4 and preoperative impaired mobility to facilitate the management of PD in elderly patients undergoing major abdominal surgery.