C
Christopher J.H. Porter
Researcher at Monash University
Publications - 305
Citations - 22996
Christopher J.H. Porter is an academic researcher from Monash University. The author has contributed to research in topics: Lymphatic system & Bioavailability. The author has an hindex of 75, co-authored 286 publications receiving 20094 citations. Previous affiliations of Christopher J.H. Porter include Oak Ridge National Laboratory & University of British Columbia.
Papers
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Journal ArticleDOI
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
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Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
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Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
TL;DR: The properties of excipients are discussed, the formulation strategies that can be used for each type of lipid formulation are outlined, and a framework for the in vitro testing of each type is suggested.
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Enhancing intestinal drug solubilisation using lipid-based delivery systems.
TL;DR: The mechanistic rationale which underpins the use of lipid-based delivery systems to enhance drug solubilisation is described and the available literature describing increases in oral bioavailability after the administration of lipid solution, suspension and self-emulsifying formulations is reviewed.
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Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH
TL;DR: Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.