C
Christopher J. Handley
Researcher at La Trobe University
Publications - 119
Citations - 4610
Christopher J. Handley is an academic researcher from La Trobe University. The author has contributed to research in topics: Proteoglycan & Aggrecan. The author has an hindex of 38, co-authored 119 publications receiving 4438 citations. Previous affiliations of Christopher J. Handley include Monash University, Clayton campus & University of Alberta.
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Journal ArticleDOI
Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.
D J McQuillan,Christopher J. Handley,Margaret A. Campbell,S. Bolis,V E Milway,Adrian C. Herington +5 more
TL;DR: In this paper, the authors showed the activity in the serum responsible for this effect to be heat-and acid-stable, associated with a high-Mr complex in normal serum but converted to a low-Mr form under acid conditions.
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Variants within the COL5A1 gene are associated with achilles tendinopathy in two populations
Alison V. September,Jill Cook,Christopher J. Handley,L van der Merwe,Martin Schwellnus,Malcolm Collins +5 more
TL;DR: The BstUI RFLP is associated with chronic Achilles tendinopathy in a second population and a region within the COL5A1 3′ untranslated region may predispose individuals to an increased risk of developing chronic Achilles Tendinopathy.
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Mechanism of catabolism of aggrecan by articular cartilage.
TL;DR: Analysis of synovial fluids and serum of age-matched animals revealed the presence of aggrecan core protein peptides corresponding in size to those detected in vitro, thus indicating the cleavage observed in explant culture is the same as that which occurs in vivo.
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The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture.
Vincent C. Hascall,Christopher J. Handley,D J McQuillan,Gretchen K. Hascall,H. Clem Robinson,Dennis A. Lowther +5 more
TL;DR: The maintenance of steady-state conditions for proteoglycan metabolism by either adult or calf tissue in the presence of serum in these cultures should provide a useful model for studying the regulation of synthesis and catabolism of proteoglycans by chondrocytes residing in a nearly normal extracellular matrix for long periods of time.
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In vitro response of chondrocytes to mechanical loading. The effect of short term mechanical tension.
TL;DR: No significant change was observed in the hydrodynamic size of the proteoglycans synthesized by chondrocytes subjected to mechanical loading, but there was a 2.4-fold increase of 3H-thymidine into DNA in cultures subjected to tensional strain, and the cellular levels of cyclic AMP increased 2.2 times in the mechanically loaded cultures.