Christopher J. Kimble

TL;DR: Results support a dopamine neuronal activation hypothesis suggesting that STN DBS evokes striatal dopamine release by stimulation of nigrostriatal dopaminergic neurons.

TL;DR: A carbon nanofiber electrode array was integrated with the Wireless Instantaneous Neurotransmitter Concentration Sensor System (WINCS) for the detection of dopamine using fast scan cyclic voltammetry (FSCV), demonstrating that CNF arrays can be utilized as an alternative carbon electrode for neurochemical monitoring.

TL;DR: The experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation shows that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.

TL;DR: The extended capability of the WINCS to use fixed potential amperometry (FPA) to measure extracellular concentrations of dopamine, as well as glutamate and adenosine, both in vitro and in vivo is described.

TL;DR: The WINCS provided reliable, high-fidelity measurements of dopamine and other neurochemicals such as serotonin, norepinephrine, and ascorbic acid by using FSCV at CFM and by flow injection analysis, and reduced susceptibility to electromagnetic noise typically found in an operating room setting.