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Christopher J. Magovern
Researcher at NewYork–Presbyterian Hospital
Publications - 16
Citations - 1629
Christopher J. Magovern is an academic researcher from NewYork–Presbyterian Hospital. The author has contributed to research in topics: Vascular endothelial growth factor A & Adipose tissue. The author has an hindex of 10, co-authored 16 publications receiving 1561 citations. Previous affiliations of Christopher J. Magovern include Cornell University.
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Journal ArticleDOI
Cerebral Oxygen Desaturation Predicts Cognitive Decline and Longer Hospital Stay After Cardiac Surgery
James P. Slater,Theresa Guarino,Jessica Stack,Kateki Vinod,Rami Bustami,John Brown,Alejandro L. Rodriguez,Christopher J. Magovern,Thomas S. Zaubler,Kenneth Freundlich,Grant V.S. Parr +10 more
TL;DR: Intraoperative cerebral oxygen desaturation is significantly associated with an increased risk of cognitive decline and prolonged hospital stay after CABG.
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Vascular Endothelial Growth Factor Is the Major Angiogenic Factor in Omentum: Mechanism of the Omentum-Mediated Angiogenesis
Qing-Xue Zhang,Christopher J. Magovern,Charles A. Mack,Kurt T. Budenbender,Wilson Ko,Todd K. Rosengart +5 more
TL;DR: Data suggest that VEGF is the major angiogenic factor produced by omentum and possibly underlies the mechanism of omentsum-induced angiogenesis.
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Circumvention of Anti-Adenovirus Neutralizing Immunity by Administration of an Adenoviral Vector of an Alternate Serotype
Charles A. Mack,Wenru Song,Heather Carpenter,Tom Wickham,Imre Kovesdi,Ben-Gary Harvey,Christopher J. Magovern,O. Wayne Isom,Todd K. Rosengart,Eric Falck-Pedersen,Neil R. Hackett,Ronald G. Crystal,Andrea Mastrangeli +12 more
TL;DR: It is demonstrated that alternate use of Ad vectors from different serotypes within the same subgroup can circumvent anti-Ad humoral immunity to permit effective gene transfer after repeat administration, although the chronicity of expression is limited.
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Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion
Charles A. Mack,Christopher J. Magovern,Kurt T. Budenbender,Shailen R. Patel,Eric A. Schwarz,Pat B. Zanzonico,Barbara Ferris,Timothy A. Sanborn,O. Wayne Isom,Ronald G. Crystal,Todd K. Rosengart +10 more
TL;DR: An adenovirus vector expressing VEGF complementary DNA is capable of stimulating an angiogenic response that protects against acute vascular occlusion in the setting of preexisting ischemia, suggesting that in vivo gene transfer of VEGf complementary DNA might be useful in prophylaxis of advancing arterial occlusive disease.
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Direct in vivo gene transfer to canine myocardium using a replication-deficient adenovirus vector
Christopher J. Magovern,Charles A. Mack,John Zhang,Rebecca T. Hahn,Ko Wilson,O. Wayne Isom,Ronald G. Crystal,Todd K. Rosengart +7 more
TL;DR: Adenovirus-mediated direct myocardial gene transfer can be accomplished safely in a large animal model, providing high levels of protein expression in a greater spatial distribution than previously reported, with minimal transfection of distant organs.