Christopher J. Zerio

TL;DR: Elatol's identification as an eIF4A1 inhibitor with in vivo antitumor activities provides proof of principle for target-based screening against this highly promising target for cancer therapy.

TL;DR: In this article, SIRT2 was used as an eraser for post-translational modification (PTM) in the context of CRISPR-Cas9 and it was shown that SIRT 2 controls the abundance of this PTM both globally and on chromatin.

TL;DR: In this article, a high throughput fluorescence polarization-based peptide binding assay was used to discover the anti-infective agent hexachlorophene as an inhibitor of glucose-regulated protein 78 (GRP78).

TL;DR: A link between arsenic and protein quality control is reported, where a misregulation of the ATPase cycle ofThe ATPase associated with various cellular activities (AAA+) chaperone, p97, results in a loss of p97 activity and the proteasome to also be compromised.

TL;DR: A Na2HPO4-catalyzed four-component reaction between a ketone, malononitrile, S8 and formamide has been realized for the first time and provides a concise approach to thieno[2,3-d]pyrimidin-4-amines, previously requiring 5 steps.