C
Christopher L. Netherton
Researcher at Institute for Animal Health
Publications - 5
Citations - 524
Christopher L. Netherton is an academic researcher from Institute for Animal Health. The author has contributed to research in topics: African swine fever virus & Viral replication. The author has an hindex of 5, co-authored 5 publications receiving 370 citations.
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Journal ArticleDOI
Dynamics of African swine fever virus shedding and excretion in domestic pigs infected by intramuscular inoculation and contact transmission
Claire Guinat,Claire Guinat,Ana Luisa Reis,Christopher L. Netherton,Lynnette Goatley,Dirk U. Pfeiffer,Linda K. Dixon +6 more
TL;DR: In this paper, the dynamics of shedding and excretion of the Georgia 2007/1 ASFV strain were measured through within-and between-pen transmission scenarios, and the results indicated that the pathogenesis of the disease might be different depending on the route of infection.
Journal ArticleDOI
Deletion of African swine fever virus interferon inhibitors from the genome of a virulent isolate reduces virulence in domestic pigs and induces a protective response
Ana Luisa Reis,Charles C. Abrams,Lynnette Goatley,Christopher L. Netherton,Dave Chapman,Pedro J. Sánchez-Cordón,Linda K. Dixon +6 more
TL;DR: The data confirms that these MGF360 and MGF530/505 genes have roles in suppressing induction of type I IFN and is a promising route for construction of rationally attenuated ASFV candidate vaccine strains.
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Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.
Josephine P. Golding,Lynnette Goatley,Steve Goodbourn,Linda K. Dixon,Geraldine Taylor,Christopher L. Netherton +5 more
TL;DR: Findings suggest that as well as inhibiting the induction of interferon, MGF360 and MGF505 genes also enable ASFV to overcome the antiviral state.
Journal ArticleDOI
Deletion of the African Swine Fever Virus Gene DP148R Does Not Reduce Virus Replication in Culture but Reduces Virus Virulence in Pigs and Induces High Levels of Protection against Challenge.
Ana Luisa Reis,Lynnette Goatley,Tamara Jabbar,Pedro J. Sánchez-Cordón,Christopher L. Netherton,David A. G. Chapman,Linda K. Dixon +6 more
TL;DR: The virus with the gene deletion, BeninΔDP148R, caused mild clinical signs in pigs and induced high levels of protection against challenge with the parental virulent virus and can provide a target for the rational development of vaccines.
Journal ArticleDOI
Different routes and doses influence protection in pigs immunised with the naturally attenuated African swine fever virus isolate OURT88/3.
Pedro J. Sánchez-Cordón,David A. G. Chapman,Tamara Jabbar,Ana Luisa Reis,Lynnette Goatley,Christopher L. Netherton,Geraldine Taylor,Maria Montoya,Linda K. Dixon +8 more
TL;DR: Results showed that factors including delivery route and dose determine the outcome of immunisation with the naturally attenuated isolate OURT88/3, and pigs immunised intramuscularly with low and moderate doses displayed lower percentages of protection, and low or undetectable levels of virus genome were detected in blood samples throughout the study.