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Christopher M. Mulligan
Researcher at Colorado State University
Publications - 7
Citations - 177
Christopher M. Mulligan is an academic researcher from Colorado State University. The author has contributed to research in topics: Docosahexaenoic acid & Cardiolipin. The author has an hindex of 6, co-authored 7 publications receiving 147 citations.
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Journal ArticleDOI
Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart
Christopher M. Mulligan,Genevieve C. Sparagna,Catherine H. Le,Anthony Bret Mooy,Melissa A. Routh,Michael Holmes,Diane L. M. Hickson-Bick,Simona Zarini,Robert C. Murphy,Fred Y. Xu,Grant M. Hatch,Sylvia A. McCune,Russell L. Moore,Adam J. Chicco +13 more
TL;DR: Moderate consumption of HLSO preserves CL and mitochondrial function in the failing heart and may be a useful adjuvant therapy for this condition.
Journal ArticleDOI
Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure.
Catherine H. Le,Christopher M. Mulligan,Melissa A. Routh,Gerrit J. Bouma,Melinda A. Frye,Kimberly M. Jeckel,Genevieve C. Sparagna,Joshua M. Lynch,Russell L. Moore,Sylvia A. McCune,Michael R. Bristow,Simona Zarini,Robert C. Murphy,Adam J. Chicco +13 more
TL;DR: A pivotal role of essential fatty acid metabolism in myocardial phospholipid remodeling induced by hemodynamic stress is demonstrated and novel links between this phenomenon and the propagation of multiple pathogenic systems involved in maladaptive cardiac remodeling and contractile dysfunction are revealed.
Journal ArticleDOI
Inhibition of Delta-6 Desaturase Reverses Cardiolipin Remodeling and Prevents Contractile Dysfunction in the Aged Mouse Heart Without Altering Mitochondrial Respiratory Function
Christopher M. Mulligan,Catherine H. Le,Anthony B. deMooy,Christopher B. Nelson,Adam J. Chicco +4 more
TL;DR: Interestingly, delta-6 desaturase inhibition had no effect on age-related mitochondrial respiratory dysfunction, H2O2 release, or lipid peroxidation but markedly attenuated cardiac dilatation, hypertrophy, and contractile dysfunction in aged mice.
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The role of dietary fatty acids in predicting myocardial structure in fat-fed rats.
Kimberly M. Jeckel,Kelsey E Miller,Adam J. Chicco,Phillip L. Chapman,Christopher M. Mulligan,Paul H. Falcone,Melissa L Miller,Michael J. Pagliassotti,Melinda A. Frye +8 more
TL;DR: Under conditions of high-fat feeding, replacement of 10% saturated fat with either LA or ALA is associated with thickening of the cranial LV wall, but without concomitant functional changes.
Journal ArticleDOI
Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria.
Catherine H. Le,Lindsay G. Benage,Kalyn S. Specht,Lance C. Li Puma,Christopher M. Mulligan,Adam L. Heuberger,Jessica E. Prenni,Steven M. Claypool,Kathryn C. Chatfield,Genevieve C. Sparagna,Adam J. Chicco +10 more
TL;DR: These findings support links among cardiolipin abnormalities, respiratory supercomplex instability, and mitochondrial oxidant production and shed new light on the distinct metabolic consequences of tafazzin deficiency in the mammalian heart.